Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jan;32(1):e22166.
doi: 10.1002/jcla.22166. Epub 2017 Feb 10.

A comparison of cystatin C concentrations between patients with chronic interstitial nephritis and glomerular diseases

Nicolas Roberto Robles  1 , Candido Mena  2 , Edgar Chavez  1 , Miguel Angel Bayo  1 , Boris Gonzalez Candia  1 , Antonio Cidoncha  3 , Juan Lopez Gomez  4 , Juan Jose Cubero  1
Affiliations

A comparison of cystatin C concentrations between patients with chronic interstitial nephritis and glomerular diseases

Nicolas Roberto Robles et al. J Clin Lab Anal. 2018 Jan.

Abstract

Aims: Cystatin C have shown to be a renal function parameter with higher sensitivity and specificity than serum creatinine. In tubular diseases, cystatin C degradation and an increase in its urinary elimination would be observed. We have tried to define if different kinds of kidney diseases may significantly affect the serum levels of cystatin C.

Design and methods: Four hundred and four patients were studied: 249 men and 155 women, mean age was 64.3±10.1 years. Patients were classified into three groups: (1) Chronic interstitial nephropathy (CIN), (2) Glomerular nephropathy (GN), and (3) Non- CKD patients (control). GFR was estimated though the CKD-EPI equation and the Hoek formula.

Results: Median of serum creatinine levels was higher in CIN group than in GN and control groups. Median cystatin C levels were lower in control group compared with CIN and GN groups. No significant differences were found between CIN group and GN group. Nevertheless, the cystatin/creatinine rate was lower in the CIN group patients (0.94, 0.81-1.11) than in the GN group (1.02,I 0.85-1.25) as well as the control group (1.02, I 0.88-1.20). The cystatin C-estimated GFR/creatinine-estimated GFR rate was higher in the CIN group (1.18, 1.03-1.36) than in the GN patients (1.03, 0.88-1.21) and control ones (1.07, 0.88-1.20).

Conclusions: Patients with CIN had lower serum levels of cystatin C defined as cystatin C/creatinine rate when they were compared with GN subject and control ones. In the same way, the index between cystatin C-estimated GFR and creatinine-estimated GFR was higher in CIN patients.

Keywords: chronic interstitial nephropathy; chronic kidney disease; cystatin C.

PubMed Disclaimer

References

    1. Abrahamson M, Olafsson I, Palsdottir A, et al. Structure and expression of the human cystatin C gene. Biochem J. 1990;268:287–294. - PMC - PubMed
    1. Tenstad O, Roald AB, Grubb A, Aukland K. Renal handling of radiolabelled human cystatin C in the rat. Scand J Clin Lab Invest. 1996;56:409–414. - PubMed
    1. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group . KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Inter Suppl. 2013;3:1–150.
    1. Waring WS, Moonie A. Earlier recognition of nephrotoxicity using novel biomarkers of acute kidney injury. Clin Toxicol (Phila). 2011;49:720–728. - PubMed
    1. Conti M, Moutereau S, Zater M, et al. Urinary cystatin C as a specific marker of tubular dysfunction. Clin Chem Lab Med. 2006;44:288–291. - PubMed