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Review
. 2017 Apr 18;8(16):27582-27592.
doi: 10.18632/oncotarget.15175.

Long non-coding RNA in glioma: signaling pathways

Jia Shi  1 , Bo Dong  1 , Jiachao Cao  1 , Yumin Mao  1 , Wei Guan  1 , Ya Peng  1 , Suinuan Wang  1
Affiliations
Review

Long non-coding RNA in glioma: signaling pathways

Jia Shi et al. Oncotarget. .

Abstract

Glioma is regarded as the most prevalent malignant carcinoma of the central nervous system. Thus, the development of new therapeutic strategies targeting glioma is of significant clinical importance. Long non-coding RNAs (lncRNAs) are functional RNA molecules without a protein-coding function and are reportedly involved in the initiation and progression of glioma. Dysregulation of lncRNAs in glioma is due to activation of several signaling pathways, such as the BRD4-HOTAIR-β-catenin/PDCD4, p53-Hif-H19/IGF2 and CRNDE/mTOR pathways. Furthermore, microRNAs (miRNAs) such as miR-675 also interact with lncRNAs in glioma. Thus, exploring the mechanisms by which lncRNA control processes will be instrumental for devising new effective therapies against glioma.

Keywords: glioma; long non-coding RNAs; microRNA.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1. Characterization of glioma cells: infiltration and heterogeneity
Infiltration: glioma cells exhibit a special growth pattern, involving sustaining proliferative activity, enabling replicative immortality, opposing growth suppressors, resisting cell death, activating angiogenesis, promoting invasion and metastasis, reprogramming energy metabolism and evading immune destruction. Heterogeneity: glioma cells recruit undifferentiated and differentiated cells to form a “tumor microenvironment” for tumorigenesis.
Figure 2
Figure 2. Mechanisms of lncRNA in glioma
A. The pro-oncogenic lncRNA network. B. The tumor-suppressive lncRNA network.
Figure 2
Figure 2. Mechanisms of lncRNA in glioma
A. The pro-oncogenic lncRNA network. B. The tumor-suppressive lncRNA network.
See this image and copyright information in PMC

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