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. 1989;24(5):447-51.

Suppression by gamma-hydroxybutyric acid of ethanol withdrawal syndrome in rats

F Fadda  1 , G Colombo, E Mosca, G L Gessa
Affiliations
  • PMID: 2818752

Suppression by gamma-hydroxybutyric acid of ethanol withdrawal syndrome in rats

F Fadda et al. Alcohol Alcohol. 1989.

Abstract

The ability of gamma-hydroxybutyric acid to suppress ethanol withdrawal syndrome was tested in male rats rendered physically dependent on ethanol by several intragastric administrations of ethanol (9-15 g/kg daily for 7 days). Gamma-hydroxybutyrate (0.25, 0.50 and 1.00 g/kg i.p.), administered 8 hr after the last ethanol dose, produced a dose-dependent inhibition of withdrawal signs such as tremors and audiogenically-induced seizures; the highest dose tested suppressed all ethanol withdrawal symptoms.

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