Internal exposure to neutron-activated 56Mn dioxide powder in Wistar rats: part 1: dosimetry

Abstract

There were two sources of ionizing irradiation after the atomic bombings of Hiroshima and Nagasaki: (1) initial gamma-neutron irradiation at the moment of detonation and (2) residual radioactivity. Residual radioactivity consisted of two components: radioactive fallout containing fission products, including radioactive fissile materials from nuclear device, and neutron-activated radioisotopes from materials on the ground. The dosimetry systems DS86 and DS02 were mainly devoted to the assessment of initial radiation exposure to neutrons and gamma rays, while only brief considerations were given for the estimation of doses caused by residual radiation exposure. Currently, estimation of internal exposure of atomic bomb survivors due to dispersed radioactivity and neutron-activated radioisotopes from materials on the ground is a matter of some interest, in Japan. The main neutron-activated radionuclides in soil dust were ²⁴Na, ²⁸Al, ³¹Si, ³²P, ³⁸Cl, ⁴²K, ⁴⁵Ca, ⁴⁶Sc, ⁵⁶Mn, ⁵⁹Fe, ⁶⁰Co, and ¹³⁴Cs. The radionuclide ⁵⁶Mn (T _1/2 = 2.58 h) is known as one of the dominant beta- and gamma emitters during the first few hours after neutron irradiation of soil and other materials on ground, dispersed in the form of dust after a nuclear explosion in the atmosphere. To investigate the peculiarities of biological effects of internal exposure to ⁵⁶Mn in comparison with external gamma irradiation, a dedicated experiment with Wistar rats exposed to neutron-activated ⁵⁶Mn dioxide powder was performed recently by Shichijo and coworkers. The dosimetry required for this experiment is described here. Assessment of internal radiation doses was performed on the basis of measured ⁵⁶Mn activity in the organs and tissues of the rats and of absorbed fractions of internal exposure to photons and electrons calculated with the MCNP-4C Monte Carlo using a mathematical rat phantom. The first results of this international multicenter study show that the internal irradiation due to incorporated ⁵⁶Mn powder is highly inhomogeneous, and that the most irradiated organs of the experimental animals are: large intestine, small intestine, stomach, and lungs. Accumulated absorbed organ doses were 1.65, 1.33, 0.24, 0.10 Gy for large intestine, small intestine, stomach, and lungs, respectively. Other organs were irradiated at lower dose levels. These results will be useful for interpretation of the biological effects of internal exposure of experimental rats to powdered ⁵⁶Mn as observed by Shichijo and coworkers.

Keywords: 56Mn; Experimental rats; Internal dosimetry; Monte Carlo simulation; Neutron activation; Radioactive dust.