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. 2017 Feb 24;80(2):235-240.
doi: 10.1021/acs.jnatprod.6b00838. Epub 2017 Feb 13.

Cultures of the Marine Bacterium Pseudovibrio denitrificans Ab134 Produce Bromotyrosine-Derived Alkaloids Previously Only Isolated from Marine Sponges

Karen J Nicacio  1 , Laura P Ióca  1 , Adriana M Fróes  2 , Luciana Leomil  2 , Luciana R Appolinario  2 , Christiane C Thompson  2 , Fabiano L Thompson  2 , Antonio G Ferreira  3 , David E Williams  4 , Raymond J Andersen  4 , Alessandra S Eustaquio  5 , Roberto G S Berlinck  1
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Cultures of the Marine Bacterium Pseudovibrio denitrificans Ab134 Produce Bromotyrosine-Derived Alkaloids Previously Only Isolated from Marine Sponges

Karen J Nicacio et al. J Nat Prod. .

Abstract

Herein we report the isolation and spectroscopic identification of fistularin-3 (1), 11-hydroxyaerothionin (2), and verongidoic acid (3), as well as the UPLC-HRMS detection of aerothionin (4), homopurpuroceratic acid B (5), purealidin L (6), and aplysinamisine II (7), from cultures of the marine bacterium Pseudovibrio denitrificans Ab134, isolated from tissues of the marine sponge Arenosclera brasiliensis. These results unambiguously demonstrate for the first time that bromotyrosine-derived alkaloids that were previously isolated only from Verongida sponges can be biosynthesized by a marine bacterium.

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