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. 2017 Apr:135:63-65.
doi: 10.1016/j.mimet.2017.02.004. Epub 2017 Feb 10.

Evaluation of two novel chemiluminescence immunoassays for the detection of Clostridium difficile glutamate dehydrogenase and toxin A&B

Annette Blaich  1 , Reno Frei  2 , Carine Castellano  2 , Christine Kiessling  2 , Angelika Geschke  3 , Katharina M Rentsch  3 , Adrian Egli  2
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Evaluation of two novel chemiluminescence immunoassays for the detection of Clostridium difficile glutamate dehydrogenase and toxin A&B

Annette Blaich et al. J Microbiol Methods. 2017 Apr.

Abstract

A novel immunoassay for Clostridium difficile glutamate dehydrogenase (GDH) and toxin A&B (LIAISON, DiaSorin) was compared to another GDH assay (Alere), PCR and toxigenic culture. The GDH-DiaSorin is slightly more sensitive than the GDH-Alere. Sensitivity of the Toxin-Diasorin test is in accordance to the sensitivity of other immunoassays in literature.

Keywords: Clostridium difficile; Glutamate dehydrogenase; Toxins A&B.

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