Review

. 2017 Mar;4(1):89-98.

doi: 10.1007/s40572-017-0126-3.

The Exposome Research Paradigm: an Opportunity to Understand the Environmental Basis for Human Health and Disease

Germaine M Buck Louis¹, Melissa M Smarr², Chirag J Patel³

Affiliations

¹ Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6710B Rockledge Drive, Room 3148, Rockville, MD, 20852, USA. louisg@mail.nih.gov.
² Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6710B Rockledge Drive, Room 3148, Rockville, MD, 20852, USA.
³ Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck St., Boston, MA, 02115, USA.

PMID: 28194614
PMCID: PMC5363405
DOI: 10.1007/s40572-017-0126-3

Review

The Exposome Research Paradigm: an Opportunity to Understand the Environmental Basis for Human Health and Disease

Germaine M Buck Louis et al. Curr Environ Health Rep. 2017 Mar.

. 2017 Mar;4(1):89-98.

doi: 10.1007/s40572-017-0126-3.

Authors

Germaine M Buck Louis¹, Melissa M Smarr², Chirag J Patel³

Affiliations

¹ Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6710B Rockledge Drive, Room 3148, Rockville, MD, 20852, USA. louisg@mail.nih.gov.
² Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6710B Rockledge Drive, Room 3148, Rockville, MD, 20852, USA.
³ Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck St., Boston, MA, 02115, USA.

PMID: 28194614
PMCID: PMC5363405
DOI: 10.1007/s40572-017-0126-3

Abstract

Purpose of review: This paper presents an overview of the exposome research paradigm with particular application to understanding human reproduction and development and its implications for health across a lifespan.

Recent findings: The exposome research paradigm has generated considerable discussion about its feasibility and utility for delineating the impact of environmental exposures on human health. Early initiatives are underway, including smaller proof-of-principle studies and larger concerted efforts. Despite the notable challenges underlying the exposome paradigm, analytic techniques are being developed to handle its untargeted approach and correlated and multi-level or hierarchical data structures such initiatives generate, while considering multiple comparisons. The relatively short intervals for critical and sensitive windows of human reproduction and development seem well suited for exposome research and may revolutionize our understanding of later onset diseases. Early initiatives suggest that the exposome paradigm is feasible, but its utility remains to be established with applications to population human health research.

Keywords: Design; Epidemiology; Exposome; Methods; Reproduction.

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Conflict of interest statement

Conflict of Interest

Germaine M. Buck Louis, Melissa M. Smarr, and Chirag J. Patel declare that they have no conflict of interest.

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The Exposome Research Paradigm: an Opportunity to Understand the Environmental Basis for Human Health and Disease

Affiliations

The Exposome Research Paradigm: an Opportunity to Understand the Environmental Basis for Human Health and Disease

Authors

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Abstract

Conflict of interest statement

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