When silencing mRNA, position matters

Affiliations

Comment

Alexandra A Mushegian. Sci Signal. 2017.

. 2017 Feb 14;10(466):eaam9537.

doi: 10.1126/scisignal.aam9537.

Abstract

The mechanism of posttranscriptional silencing by an RNA-binding protein depends on the position of the protein-binding sequence in the mRNA.

LIN41 Post-transcriptionally Silences mRNAs by Two Distinct and Position-Dependent Mechanisms.
Aeschimann F, Kumari P, Bartake H, Gaidatzis D, Xu L, Ciosk R, Großhans H. Aeschimann F, et al. Mol Cell. 2017 Feb 2;65(3):476-489.e4. doi: 10.1016/j.molcel.2016.12.010. Epub 2017 Jan 19. Mol Cell. 2017. PMID: 28111013
When LIN41 Comes to a Fork in the Road, It Takes BOTH Paths: Translational Repression OR mRNA Decay, Depending on the Target Site Position.
Hand JM, Bazzini AA. Hand JM, et al. Mol Cell. 2017 Feb 2;65(3):375-377. doi: 10.1016/j.molcel.2017.01.018. Mol Cell. 2017. PMID: 28157501