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Review
. 2017:2017:3187594.
doi: 10.1155/2017/3187594. Epub 2017 Jan 19.

Sirtuins Expression and Their Role in Retinal Diseases

Sankarathi Balaiya  1 , Khaled K Abu-Amero  2 , Altaf A Kondkar  3 , Kakarla V Chalam  4
Affiliations
Review

Sirtuins Expression and Their Role in Retinal Diseases

Sankarathi Balaiya et al. Oxid Med Cell Longev. 2017.

Abstract

Sirtuins have received considerable attention since the discovery that silent information regulator 2 (Sir2) extends the lifespan of yeast. Sir2, a nicotinamide adenine dinucleotide- (NAD-) dependent histone deacetylase, serves as both a transcriptional effector and energy sensor. Oxidative stress and apoptosis are implicated in the pathogenesis of neurodegenerative eye diseases. Sirtuins confer protection against oxidative stress and retinal degeneration. In mammals, the sirtuin (SIRT) family consists of seven proteins (SIRT1-SIRT7). These vary in tissue specificity, subcellular localization, and enzymatic activity and targets. In this review, we present the current knowledge of the sirtuin family and discuss their structure, cellular location, and biological function with a primary focus on their role in different neuroophthalmic diseases including glaucoma, optic neuritis, and age-related macular degeneration. The potential role of certain therapeutic targets is also described.

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Conflict of interest statement

The authors declare they have no competing interests.

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