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Comment
. 2017 Feb 15;595(4):1025-1026.
doi: 10.1113/JP273649.

Inflammation and cardiovascular autonomic dysfunction in rheumatoid arthritis: a bidirectional pathway leading to cardiovascular disease

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Comment

Inflammation and cardiovascular autonomic dysfunction in rheumatoid arthritis: a bidirectional pathway leading to cardiovascular disease

Tiago Peçanha et al. J Physiol. .
No abstract available

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Figures

Figure 1
Figure 1. Neural–immune imbalance as integral components of the cardiovascular disease continuum
The aggravation of this vicious cycle will promote further prejudice to the cardiovascular system. ACh, acetylcholine; hs‐CRP, high sensitivity C‐reactive protein; IL‐6, interleukin‐6; NE, noradrenaline; TNF‐α, tumour necrosis factor α. [Colour figure can be viewed at wileyonlinelibrary.com]

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References

    1. Adlan AM, Paton JFR, Lip GYH, Kitas GD & Fisher JP (2017). Increased sympathetic nerve activity and reduced cardiac baroreflex sensitivity in rheumatoid arthritis. J Physiol 595, 967–981. - PMC - PubMed
    1. Janse van Rensburg DC, Ker JA, Grant CC & Fletcher L (2012). Effect of exercise on cardiac autonomic function in females with rheumatoid arthritis. Clin Rheumatol 31, 1155–1162. - PubMed
    1. Koopman FA, Chavan SS, Miljko S, Grazio S, Sokolovic S, Schuurman PR, Mehta AD, Levine YA, Faltys M, Zitnik R, Tracey KJ & Tak PP (2016). Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis. Proc Natl Acad Sci USA 113, 8284–8289. - PMC - PubMed
    1. Suzuki K & Nakai A (2016). Autonomic control of inflammation. Clin Exp Neuroimmunol 7, 10–17.
    1. Syngle A, Verma I, Krishan P, Garg N & Syngle V (2015). Disease‐modifying anti‐rheumatic drugs improve autonomic neuropathy in arthritis: DIANA study. Clin Rheumatol 34, 1233–1241. - PubMed

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