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. 2017 Feb 15:7:42366.
doi: 10.1038/srep42366.

HIV cause-specific deaths, mortality, risk factors, and the combined influence of HAART and late diagnosis in Zhejiang, China, 2006-2013

Lin Chen  1 , Xiaohong Pan  1 , Qiaoqin Ma  1 , Jiezhe Yang  1 , Yun Xu  1 , Jinlei Zheng  1 , Hui Wang  1 , Xin Zhou  1 , Tingting Jiang  1 , Jun Jiang  1 , Lin He  1 , Jianmin Jiang  1
Affiliations

HIV cause-specific deaths, mortality, risk factors, and the combined influence of HAART and late diagnosis in Zhejiang, China, 2006-2013

Lin Chen et al. Sci Rep. .

Abstract

To examine patterns of human immunodeficiency virus (HIV) cause-specific deaths, risk factors, and the effect of interactions on mortality, we conducted a retrospective cohort study in Zhejiang, China, from 2006 to 2013. All data were downloaded from the acquired immune deficiency syndrome (AIDS) Prevention and Control Information System. The Cox proportional hazards model was used to assess predictors of cause-specific death. The relative excess risk due to interaction and ratio of hazard ratios (RHR) were calculated for correlations between HAART, late diagnosis, and age. A total of 13,812 HIV/AIDS patients were enrolled with 31,553 person-years (PY) of follow-up. The leading causes of death of HIV patients were accidental death and suicide (21.5%), and the leading cause of death for those with AIDS was AIDS-defining disease (76.4%). Both additive and multiplicative scale correlations were found between receiving HAART and late diagnosis, with RERI of 5.624 (95% CI: 1.766-9.482) and RHR of 2.024 (95% CI: 1.167-2.882). The effects of HAART on AIDS-related mortalities were affected by late diagnosis. Early detection of HIV infection and increased uptake of HAART are important for greater benefits in terms of lives saved.

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Conflict of interest statement

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1. Study design flow chart for the human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) cohort study, 2006–2013.
Figure 2
Figure 2. Mortality rate among HIV/AIDS patients in 2006–2013.
Figure 3
Figure 3. Mortality rate among AIDS patients in 2006–2013.
Figure 4
Figure 4. Death rates in HIV/AIDS patients, AIDS patients, and the population in Zhejiang province, 2006–2013.
Figure 5
Figure 5. The proportion of late diagnosis among HIV/AIDS in 2006–2013.
See this image and copyright information in PMC

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