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. 1987 Sep;84(17):6179-83.
doi: 10.1073/pnas.84.17.6179.

Macrophages specifically regulate the concentration of their own growth factor in the circulation

A Bartocci, D S Mastrogiannis, G Migliorati, R J Stockert, A W Wolkoff, E R Stanley

Macrophages specifically regulate the concentration of their own growth factor in the circulation

A Bartocci et al. Proc Natl Acad Sci U S A. 1987 Sep.

Abstract

The physiological mechanism of clearance of the mononuclear phagocyte growth factor, colony-stimulating factor 1 (CSF-1), from the circulation of normal mice was investigated by following the fate of a trace amount of i.v. injected 125I-labeled CSF-1. Macrophages selectively cleared CSF-1 by CSF-1 receptor-mediated endocytosis and degraded the growth factor intracellularly. This manner of clearance provides a feedback control mechanism whereby the rate of macrophage production is determined by the number of mature macrophages.

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References

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