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Comment
. 2017 Feb 15;195(4):420-421.
doi: 10.1164/rccm.201609-1896ED.

Mitochondrial Calcium Transport: A Potentially Prominent, Therapeutically Targetable Contributor to Pulmonary Arterial Hypertension Progression

Sachin A Gupte  1 , Michael S Wolin  1
Affiliations
Comment

Mitochondrial Calcium Transport: A Potentially Prominent, Therapeutically Targetable Contributor to Pulmonary Arterial Hypertension Progression

Sachin A Gupte et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Model showing how down-regulation of the mitochondrial calcium uniporter by microRNA (miR)-25 and miR-138 in pulmonary arterial hypertension (PAH) could alter mitochondrial and extramitochondrial calcium (cytosol) levels in ways that drive metabolic changes in pulmonary arterial smooth muscle cells potentially linked to processes contributing to PAH-associated vascular remodeling. PASMC = pulmonary arterial smooth muscle cell; PDH = pyruvate dehydrogenase.
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