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Randomized Controlled Trial
. 2017 Feb 15;17(1):112.
doi: 10.1186/s12906-017-1614-6.

Acupuncture for acute moderate thalamic hemorrhage: randomized controlled trial study protocol

Chengwei Wang  1 , Chao You  2 , Lu Ma  2 , Mengyue Liu  1 , Meng Tian  2 , Ning Li  3
Affiliations
Randomized Controlled Trial

Acupuncture for acute moderate thalamic hemorrhage: randomized controlled trial study protocol

Chengwei Wang et al. BMC Complement Altern Med. .

Abstract

Background: Thalamic hemorrhage (TH) is a neurological insult with a high rate of morbidity and mortality. Moderate TH (10-30 ml) accounts for more than half of all TH. Treatment remains controversial. The role of acupuncture in patients with moderate TH is not clear.

Methods: We will conduct a single-center, randomized, parallel group, and assessor-blinded clinical trial. A total of 488 patients with moderate TH will be randomly assigned to one of eight groups: 10-15 cc left sided TH study group (N = 61) and a corresponding control group (N = 61), 10-15 cc right sided TH study group (N = 61) and a corresponding control group, 15-30 cc left sided TH study group (N = 61) and a corresponding control group (N = 61), and 15-30 cc right sided TH study group (N = 61) and a corresponding control group. Study groups will receive acupuncture in addition to standard treatment, while control groups will receive standard treatment alone. The primary outcome will be change in National Institutes of Health Stroke Scale scores at 30 and 90 days after TH. The secondary outcomes will be death or major disability, defined as a score of 3 to 6 on the modified Rankin scale (in which a score of 0 indicates no symptoms, a score of 5 indicates severe disability, and a score of 6 indicates death) at 90-days, need for surgery at 30-days, Glasgow Outcome Scale (GOS) score at 90-days following TH onset, and the results of several additional group specific tests. The rate of adverse events will then be compared between the groups.

Discussion: This study will attempt to answer the question of whether or not acupuncture can improve neurologic outcome following moderate TH. TRIAL REGISTRATION: Chinese clinical trial registry (ChiCTR-IOR-16008362).

Keywords: Acupuncture; Intracranial hemorrhage; Moderate thalamic hemorrhage; RCT.

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Figures

Fig. 1
Fig. 1
The flow chart. Patients in acupuncture group will receive 36 sessions acupuncture treatment, 6 days a weeks for 6 weeks, in addition to conventional treatments and patients in control group will receive conventional TH treatments only. LSTH, left-sided thalamic hemorrhage; RSTH, right-sided thalamic hemorrhage
See this image and copyright information in PMC

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