The clone wars

Affiliations

Comment

Himisha Beltran. Sci Transl Med. 2017.

. 2017 Feb 15;9(377):eaam6061.

doi: 10.1126/scitranslmed.aam6061.

¹ Division of Medical Oncology, Weill Cornell Medicine, New York, NY 10021, USA. Email: hip9004@med.cornell.edu.

Abstract

Genome sequencing of patients with pancreatic adenocarcinoma reveals high concordance of driver alterations across metastases.

Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer.
Makohon-Moore AP, Zhang M, Reiter JG, Bozic I, Allen B, Kundu D, Chatterjee K, Wong F, Jiao Y, Kohutek ZA, Hong J, Attiyeh M, Javier B, Wood LD, Hruban RH, Nowak MA, Papadopoulos N, Kinzler KW, Vogelstein B, Iacobuzio-Donahue CA. Makohon-Moore AP, et al. Nat Genet. 2017 Mar;49(3):358-366. doi: 10.1038/ng.3764. Epub 2017 Jan 16. Nat Genet. 2017. PMID: 28092682 Free PMC article.