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Review
. 2017 Feb 2:13:259-267.
doi: 10.2147/NDT.S128807. eCollection 2017.

Role of prediabetes in stroke

Milija D Mijajlović  1 , Vuk M Aleksić  2 , Nadežda M Šternić  1 , Mihailo M Mirković  3 , Natan M Bornstein  4
Affiliations
Review

Role of prediabetes in stroke

Milija D Mijajlović et al. Neuropsychiatr Dis Treat. .

Abstract

Stroke is one of the leading causes of death and probably the greatest cause of adult disability worldwide. Diabetes mellitus (DM) is a state of accelerated aging of blood vessels. Patients with diabetes have increased risk of stroke. Hyperglycemia represents a risk factor for poor outcome following stroke, and probably is just a marker of poor outcome rather than a cause. Lowering of blood glucose levels has not been shown to improve prognosis. Also, prevention of stroke risk among patients with DM is not improved with therapy for reduction of glucose levels. On the other hand, prediabetes, a metabolic state between normal glucose metabolism and diabetes, is a risk factor for the development of DM type 2 and subsequently for stroke. Several methods are known to identify prediabetes patients, including fasting plasma glucose levels, 2-hour post load glucose levels, and glycosylated hemoglobin levels. In this text, we tried to summarize known data about diagnosis, epidemiology, risk factors, pathophysiology, and prevention of prediabetes in relation to DM and stroke.

Keywords: diabetes mellitus; insulin; metabolic syndrome; prediabetes; risk factors; stroke.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Cutoff values for prediabetes and DM. Note: Values are in mmol/L for 2-hour post load glucose and fasting plasma glucose and in mmol/mol for glycosylated hemoglobin. Abbreviation: DM, diabetes mellitus.
See this image and copyright information in PMC

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