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Review
. 2017 Feb 1:13:347-355.
doi: 10.2147/NDT.S122016. eCollection 2017.

Use of transcranial direct current stimulation for the treatment of auditory hallucinations of schizophrenia - a systematic review

Pedro H Pondé  1 , Eduardo P de Sena  2 , Joan A Camprodon  3 , Arão Nogueira de Araújo  2 , Mário F Neto  4 , Melany DiBiasi  5 , Abrahão Fontes Baptista  6 , Lidia Mvr Moura  7 , Camila Cosmo  8
Affiliations
Review

Use of transcranial direct current stimulation for the treatment of auditory hallucinations of schizophrenia - a systematic review

Pedro H Pondé et al. Neuropsychiatr Dis Treat. .

Abstract

Introduction: Auditory hallucinations are defined as experiences of auditory perceptions in the absence of a provoking external stimulus. They are the most prevalent symptoms of schizophrenia with high capacity for chronicity and refractoriness during the course of disease. The transcranial direct current stimulation (tDCS) - a safe, portable, and inexpensive neuromodulation technique - has emerged as a promising treatment for the management of auditory hallucinations.

Objective: The aim of this study is to analyze the level of evidence in the literature available for the use of tDCS as a treatment for auditory hallucinations in schizophrenia.

Methods: A systematic review was performed, searching in the main electronic databases including the Cochrane Library and MEDLINE/PubMed. The searches were performed by combining descriptors, applying terms of the Medical Subject Headings (MeSH) of Descriptors of Health Sciences and descriptors contractions. PRISMA protocol was used as a guide and the terms used were the clinical outcomes ("Schizophrenia" OR "Auditory Hallucinations" OR "Auditory Verbal Hallucinations" OR "Psychosis") searched together ("AND") with interventions ("transcranial Direct Current Stimulation" OR "tDCS" OR "Brain Polarization").

Results: Six randomized controlled trials that evaluated the effects of tDCS on the severity of auditory hallucinations in schizophrenic patients were selected. Analysis of the clinical results of these studies pointed toward incongruence in the information with regard to the therapeutic use of tDCS with a view to reducing the severity of auditory hallucinations in schizophrenia. Only three studies revealed a therapeutic benefit, manifested by reductions in severity and frequency of auditory verbal hallucinations in schizophrenic patients.

Conclusion: Although tDCS has shown promising results in reducing the severity of auditory hallucinations in schizophrenic patients, this technique cannot yet be used as a therapeutic alternative due to lack of studies with large sample sizes that portray the positive effects that have been described.

Keywords: auditory hallucinations; non-invasive brain stimulation; schizophrenia; tDCS.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Flow diagram of selection process.
See this image and copyright information in PMC

References

    1. Kuo MF, Paulus W, Nitsche MA. Therapeutic effects of non-invasive brain stimulation with direct currents (tDCS) in neuropsychiatric diseases. Neuroimage. 2014;85(Pt 3):948–960. - PubMed
    1. Frangou S. Schizophrenia. Medicine. 2008;36(8):405–409.
    1. McGrath J, Saha S, Chant D, Welham J. Schizophrenia: a concise overview of incidence, prevalence, and mortality. Epidemiol Rev. 2008;30:67–76. - PubMed
    1. Picchioni MM, Murray RM. Schizophrenia. BMJ. 2007;335(7610):91–95. - PMC - PubMed
    1. Howes OD, Murray RM. Schizophrenia: an integrated sociodevelop-mental-cognitive model. Lancet. 2014;383(9929):1677–1687. - PMC - PubMed

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