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Case Reports
. 2017 Jan 27;11(1):23-28.
doi: 10.1159/000452735. eCollection 2017 Jan-Apr.

Black Cohosh Hepatotoxicity with Autoimmune Hepatitis Presentation

Diana L Franco  1 , Santosh Kale  1 , Dora M Lam-Himlin  1 , M Edwyn Harrison  1
Affiliations
Case Reports

Black Cohosh Hepatotoxicity with Autoimmune Hepatitis Presentation

Diana L Franco et al. Case Rep Gastroenterol. .

Abstract

Herbal medicines have been used for the treatment of various ailments since time immemorial. Black cohosh (BC) is well known for the treatment of postmenopausal symptoms, with conflicting evidence supporting its safety and benefits. We present a rare case of BC-induced autoimmune hepatitis (AIH) with hepatotoxicity in a 69-year-old female. To our knowledge, this represents the third case of BC-induced AIH.

Keywords: Autoimmune hepatitis presentation; Black cohosh; Hepatotoxicity.

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Figures

Fig. 1
Fig. 1
Histologic sections show an prominent interface and lobular hepatitis. Hematoxylin and eosin. Original magnification, ×10.
Fig. 2
Fig. 2
Higher magnification highlights the plasma cell-rich infiltrate and single necrotic hepatocytes. A few eosinophils are also present, suggesting an element of drug-induced liver injury. Hematoxylin and eosin. Original magnification, ×40.
See this image and copyright information in PMC

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