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Case Reports
. 2017 Jan 17;10(1):66-76.
doi: 10.1159/000455188. eCollection 2017 Jan-Apr.

Gastrointestinal Stromal Tumour with Synchronous Bone Metastases: A Case Report and Literature Review

Philippe Rochigneux  1 , Lénaig Mescam-Mancini  2 , Delphine Perrot  1 , Erwan Bories  3 , Laurence Moureau-Zabotto  4 , Anthony Sarran  5 , Jérôme Guiramand  6 , François Bertucci  7
Affiliations
Case Reports

Gastrointestinal Stromal Tumour with Synchronous Bone Metastases: A Case Report and Literature Review

Philippe Rochigneux et al. Case Rep Oncol. .

Abstract

Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours of the digestive tract, derived from Cajal interstitial cells. Bone metastases are very rare, and there is no consensus regarding their treatment. Here, we present the unusual case of a 66-year-old man with a gastric GIST with synchronous bone and liver metastases, fully documented at the pathological and molecular levels with a KIT exon 11 mutation. After 9 months of imatinib, the scanner showed a 33% partial response of target lesions. We also review the literature and describe the characteristics, treatment, and outcome of all cases previously reported.

Keywords: Bone metastases; Gastrointestinal stromal tumours; Imatinib; KIT; Tyrosine kinase inhibitors.

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Figures

Fig. 1
Fig. 1
Gastrointestinal stromal tumour (GIST) with liver and bone metastases: radiological aspects. a Thoraco-abdomino-pelvic CT scan in the coronal plane showing the huge gastric GIST (star) and multiple bilateral liver metastases (arrows). b, c Magnetic resonance imaging of the spine in the sagittal plane, T2 sequence, showing the multiple bone vertebral lesions (notably in C7, T1, and T9), the sacrum, and a T1 and T9 epiduritis (arrows).
Fig. 2
Fig. 2
Gastrointestinal stromal tumour (GIST) with liver and bone metastases: pathological aspects. a–c HES microphotographies showing 2 distinctive morphological patterns of GIST: epithelioid cells on gastric biopsy (a) as well as spindle cells on hepatic (b) and bone (c) metastases. d–f Immunohistochemistry staining showing expression by tumour cells (epithelioid and spindle cells) of CD117/KIT (d–f) and DOG1 (e).
Fig. 3
Fig. 3
99mTc-labelled bone scintigraphy showing multiple lesions (bone uptakes) of the cervico-dorso-lumbar spine, the pelvis, the ribs, and the clavicles.
See this image and copyright information in PMC

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