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. 2017 Jan 19;5(1):2325967116680815.
doi: 10.1177/2325967116680815. eCollection 2017 Jan.

Intra-articular Implantation of Mesenchymal Stem Cells, Part 1: A Review of the Literature for Prevention of Postmeniscectomy Osteoarthritis

Matthew J Kraeutler  1 , Justin J Mitchell  2 , Jorge Chahla  3 , Eric C McCarty  1 , Cecilia Pascual-Garrido  1
Affiliations

Intra-articular Implantation of Mesenchymal Stem Cells, Part 1: A Review of the Literature for Prevention of Postmeniscectomy Osteoarthritis

Matthew J Kraeutler et al. Orthop J Sports Med. .

Abstract

Osteoarthritis (OA) after a partial or total meniscectomy procedure is a common pathology. Because of the high incidence of meniscectomy in the general population, as well as the significant burden of knee OA, there is increasing interest in determining methods for delaying postmeniscectomy OA. Biological therapies, including mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and platelet-rich plasma (PRP), have been proposed as possible therapies that could delay OA in this and other settings. Several studies in various animal models have evaluated the effect of injecting MSCs into the knee joints of animals with OA induced either by meniscal excision with or without anterior cruciate ligament transection. When compared with control groups receiving injections without progenitor cells, short-term benefits in the experimental groups have been reported. In human subjects, there are limited data to determine the effect of biological therapies for use in delaying or preventing the onset of OA after a meniscectomy procedure. The purpose of this review is to highlight the findings in the presently available literature on the use of intra-articular implantation of MSCs postmeniscectomy and to offer suggestions for future research with the goal of delaying or treating early OA postmeniscectomy with MSCs.

Keywords: knee osteoarthritis; meniscectomy; mesenchymal stem cells; osteoarthritis.

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Conflict of interest statement

One or more of the authors has declared the following potential conflict of interest or source of funding: E.C.M. receives research support from Biomet, Mitek, Smith & Nephew, and Stryker; and is a paid consultant for and receives royalties from Biomet.

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