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. 2017 Feb 3;4(2):e326.
doi: 10.1212/NXI.0000000000000326. eCollection 2017 Mar.

Paraneoplastic cerebellar degeneration associated with anti-ITPR1 antibodies

Giulia Berzero  1 , Yael Hacohen  1 , Lars Komorowski  1 , Madeleine Scharf  1 , Caroline Dehais  1 , Delphine Leclercq  1 , Virginie Fourchotte  1 , Bruno Buecher  1 , Jérôme Honnorat  1 , Francesc Graus  1 , Jean-Yves Delattre  1 , Dimitri Psimaras  1
Affiliations

Paraneoplastic cerebellar degeneration associated with anti-ITPR1 antibodies

Giulia Berzero et al. Neurol Neuroimmunol Neuroinflamm. .
No abstract available

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Figures

Figure 1
Figure 1. MRI features and immunopathology
MRI features (A, B). Brain MRI obtained in 2007 showed an already severe pontocerebellar atrophy in sagittal T1- (A) and axial T2- (B) weighted images. Hot cross bun sign, marked enlargement of cerebellar sulci, fourth ventricle, and basal cisternae are evident in T2-weighted images (B). Immunopathology (C–F). Patient's breast cancer specimen (C, E) incubated with anti–inositol 1,4,5-trisphosphate receptor 1 (ITPR1) rabbit commercial antibody 1:1,000 (C) and control rabbit serum (E). The lymph node metastasis specimen (D, F) incubated with anti-ITPR1 rabbit commercial antibody 1:1,000 (D) and control rabbit serum (F). Magnification ×200.
See this image and copyright information in PMC

References

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