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. 2018 Jan;32(1):e22160.
doi: 10.1002/jcla.22160. Epub 2017 Feb 15.

Trace elements in children suffering from sickle cell anemia: A case-control study

Joseph K Sungu  1 , Olivier Mukuku  1 , Augustin Mulangu Mutombo  1 , Paul Mawaw  2 , Michel N Aloni  3 , Oscar N Luboya  1   2
Affiliations

Trace elements in children suffering from sickle cell anemia: A case-control study

Joseph K Sungu et al. J Clin Lab Anal. 2018 Jan.

Abstract

Background: Information on serum albumin and trace elements among children suffering from Sickle Cell Anemia (SCA) was poorly documented in Africa. The aim of this study was to describe and to compare different values of trace elements with published reports from other parts of the world.

Methods: We carried out a case-control study. Seventy-six steady state children suffering from SCA (Hb-SS). One hundred and fifty-two children were recruited with 76 (cases, Hb-SS) and 76 (control, Hb-AA) to compare the data.

Results: The mean age was 10.0 years (SD=5.4) in SCA children and 9.2 years (SD=4.7) in the control group. The mean level of zinc and magnesium were slightly lower in the Hb-SS group than in the Hb-AA group (P<.001).

Conclusion: The first literature about trace elements in SCA is briefly reported in Central Africa. In our midst, zinc, magnesium, and selenium deficiencies underline the need for their systematic among all children with SCA to identify patients with these deficiencies and provide early management.

Keywords: Democratic Republic of Congo; Lubumbashi; children; sickle cell anemia; trace elements.

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