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. 2017 Feb 9;22(6):30461.
doi: 10.2807/1560-7917.ES.2017.22.6.30461.

Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014

Laurent Dortet  1   2   3   4 , Gaëlle Cuzon  1   2   3   4 , Valérie Ponties  5 , Patrice Nordmann  6   7   8
Affiliations

Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014

Laurent Dortet et al. Euro Surveill. .

Abstract

In 2014, a total of 2,976 Enterobacteriaceae isolates with decreased susceptibility to carbapenems were received at the French Associated National Reference Center for Antibiotic Resistance (NRC) and were characterised for their molecular resistance mechanism to carbapenems and compared with results obtained during 2012 and 2013.The overall number of enterobacterial isolates with decreased susceptibility to carbapenems received at the NRC rapidly increased (more than twofold in two years) with a growing proportion of carbapenemase producers (23.1% in 2012 vs 28.6% in 2013 vs 36.2% in 2014). Between 2012 and 2014, the main carbapenemase type was OXA-48, with an increase in OXA-48 variants (mostly OXA-181) and NDM producers, whereas the number KPC producers decreased. We identified a potential spread of OXA-181 producers in the tropical region of Africa. Finally, OXA-48 and OXA-48-related enzymes remained the predominant carbapenemases in France. The number of carbapenemase-producing Escherischia coli isolates was multiplied by fivefold between 2012 and 2014, suggesting a possible dissemination in the community.

Keywords: K. pneumoniae; KPC; NDM; OXA-181; OXA-48; multidrug resistance, France.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Geographic distribution of A. Isolates received at the French Associated National Reference Center for Antibiotic Resistance B. Carbapenemase-producing Enterobacteriaceae C. OXA-48-like-, NDM-, VIM-, KPC-, IMP- and IMI-producers, France, 2012–2014
Figure 2
Figure 2
Distribution of carbapenemase-producing Enterobacteriaceae and non-carbapenemase-producing isolates by year, France, 2012–2014
Figure 3
Figure 3
Distribution of OXA-48 variants among OXA-48-like carbapenemases by year, France, 2012–2014
Figure 4
Figure 4
Known geographic origin of possible acquisition of infections and/or colonisations with carbapenemase-producing Enterobacteriaceae, France, 2014 (n=140)
Figure 5
Figure 5
A. Known geographic origin of possible acquisition of infections or colonisation with NDM- and VIM-producing Enterobacteriaceae (n=44) B. KPC-producing Enterobacteriaceae (n=4) C. OXA-48-like- producing Enterobacteriaceae (n=94), France, 2014
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References

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