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. 2017 Feb 9;22(6):30460.
doi: 10.2807/1560-7917.ES.2017.22.6.30460.

Interim estimates of 2016/17 vaccine effectiveness against influenza A(H3N2), Canada, January 2017

Danuta M Skowronski  1   2 , Catharine Chambers  1 , Suzana Sabaiduc  1 , James A Dickinson  3 , Anne-Luise Winter  4 , Gaston De Serres  5   6   7 , Steven J Drews  8   9 , Agatha Jassem  1   2 , Jonathan B Gubbay  4   10 , Hugues Charest  5 , Robert Balshaw  1   2 , Nathalie Bastien  11 , Yan Li  11 , Mel Krajden  1   2
Affiliations

Interim estimates of 2016/17 vaccine effectiveness against influenza A(H3N2), Canada, January 2017

Danuta M Skowronski et al. Euro Surveill. .

Abstract

Using a test-negative design, the Canadian Sentinel Practitioner Surveillance Network (SPSN) assessed interim 2016/17 influenza vaccine effectiveness (VE) against dominant influenza A(H3N2) viruses considered antigenically matched to the clade 3C.2a vaccine strain. Sequence analysis revealed substantial heterogeneity in emerging 3C.2a1 variants by province and over time. Adjusted VE was 42% (95% confidence interval: 18-59%) overall, with variation by province. Interim virological and VE findings reported here warrant further investigation to inform potential vaccine reformulation.

Keywords: effectiveness; influenza; influenza virus; influenza-like illness - ILI; vaccine-preventable diseases; vaccines and immunisation.

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Conflict of interest statement

Conflict of interest: Within 36 months of manuscript submission, GDS has received grants unrelated to influenza from GSK and Pfizer and travel reimbursement to attend an ad hoc advisory board meeting of GSK also unrelated to influenza; he has provided paid expert testimony in a grievance against a vaccinate-or-mask healthcare worker influenza vaccination policy for the Ontario Nurse Association. JBG has received research grants from GlaxoSmithKline Inc. and Hoffman-La Roche Ltd to study antiviral resistance in influenza, and from Pfizer Inc. to conduct microbiological surveillance of Streptococcus pneumoniae. MK has received research grants from Roche, Merck, Siemens, Hologic, and Boerhinger Ingelheim for unrelated studies. Other authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Influenza detections by type/subtype/clade and week of specimen collection, Canadian Sentinel Practitioner Surveillance Network, 2 October 2016–21 January 2017 (n = 1,096)a
Figure 2
Figure 2
Distribution of clade 3C.2a1 variants by provincea and week of specimen collection, Canadian Sentinel Practitioner Surveillance Network (SPSN), 1 November 2016−16 January 2017 (n = 176)
See this image and copyright information in PMC

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