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. 2017 Feb 17;120(4):630-632.
doi: 10.1161/CIRCRESAHA.116.310051.

Mammalian Heart Regeneration: The Race to the Finish Line

Stefanie A Doppler  1 , Marcus-Andre Deutsch  1 , Vahid Serpooshan  1 , Guang Li  1 , Elda Dzilic  1 , Rüdiger Lange  1 , Markus Krane  2 , Sean M Wu  2
Affiliations

Mammalian Heart Regeneration: The Race to the Finish Line

Stefanie A Doppler et al. Circ Res. .

Abstract

A long-standing goal of cardiovascular scientists is to repair damaged hearts following myocardial infarction by overcoming the limited regenerative capacity of the adult mammalian heart. A number of new strategies are being actively investigated for generating functional cardiomyocytes or progenitor cells. The race is on for the first demonstration of durable therapeutic heart repair in human.

Keywords: cell cycle; myocardial infarction; regenerative medicine; stem cell cardiac patch.

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Conflict of interest statement

Conflict of Interest

None

Figures

Figure 1
Figure 1
Many promising strategies to repair and recover failing myocardium are actively being explored. These include stimulation of endogenous cells, delivery of exogenous cells, and the direct conversion of fibroblasts into CMs or CPCs. Abbreviations: MSCs: mesenchymal stem cells, SMCs: smooth muscle cells, ECs: endothelial cells, CFs: cardiac fibroblasts, iSMCs: induced SMCs, iECs: induced ECs.
See this image and copyright information in PMC

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