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Comment
. 2017 Feb 2:8:53.
doi: 10.3389/fphys.2017.00053. eCollection 2017.

Commentary: ATP: The crucial component of secretory vesicles: Accelerated ATP/insulin exocytosis and prediabetes

Chitharanjan Duvoor  1 , Vijaya S Dendi  2 , Asween Marco  3 , Nawal S Shekhawat  4 , Aditya Chada  5 , Rahul Ravilla  6 , Chaitanya K Musham  7 , Wasique Mirza  8 , Arun Chaudhury  9
Affiliations
Comment

Commentary: ATP: The crucial component of secretory vesicles: Accelerated ATP/insulin exocytosis and prediabetes

Chitharanjan Duvoor et al. Front Physiol. .
No abstract available

Keywords: ATP; SLC17A9; cell secretion; diabetes mellitus; exocytosis; purinergic.

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Figures

Figure 1
Figure 1
ATP may contribute to colligative property of insulin containing vesicles (A). Note the exocytotic insulin vesicle and the dense insulin cluster in the electron micrograph. Recent study by Estévez-Herrera et al. (2016) suggest that ATP may contribute to colligative and osmotic balance of peptide containing vesicles. Such may be true for insulin vesicles (B). ATP and insulin colocalize in beta cells of pancreas. Scale bar, 2 μm (C). During exocytosis, both ATP and insulin are co-released. This co-release may have wide implications as discussed in the commentary (D). In SLC17A9 knockout, the insulin containing vesicles are not altered in number or appearance (E). In SLC17A9 knockout, the ATP and insulin contents of vesicles are decreased. But note that insulin exocytosis in SLC17A9 knockout is accelerated. This may occur due to lack of formation of ATP-(insulin)n polymer. This rapid exocytosis is a feature of early prediabetic state, as well as seen in progressive type II diabetes mellitus. Reproduced with permission from Sakamoto et al. (2014) and Liu et al. (2014). *Significance.
See this image and copyright information in PMC

Comment on

  • ATP: The crucial component of secretory vesicles.
    Estévez-Herrera J, Domínguez N, Pardo MR, González-Santana A, Westhead EW, Borges R, Machado JD. Estévez-Herrera J, et al. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):E4098-106. doi: 10.1073/pnas.1600690113. Epub 2016 Jun 24. Proc Natl Acad Sci U S A. 2016. PMID: 27342860 Free PMC article.

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