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. 2017 Apr;32(4):628-629.
doi: 10.1002/mds.26953. Epub 2017 Feb 17.

Adaptive deep brain stimulation controls levodopa-induced side effects in Parkinsonian patients

Manuela Rosa  1 , Mattia Arlotti  1   2 , Sara Marceglia  1   3 , Filippo Cogiamanian  4 , Gianluca Ardolino  4 , Alessio Di Fonzo  5 , Leonardo Lopiano  6 , Emma Scelzo  1 , Aristide Merola  6 , Marco Locatelli  7 , Paolo M Rampini  7 , Alberto Priori  1   8
Affiliations

Adaptive deep brain stimulation controls levodopa-induced side effects in Parkinsonian patients

Manuela Rosa et al. Mov Disord. 2017 Apr.
No abstract available

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Figures

Figure 1
Figure 1
(A) Experimental design of each experimental session. Clinical effects were evaluated using the motor part of the Unified PD Rating Scale (UPDRS III) and the Unified Dyskinesia Rating Scale (UDysRS III and IV) during the concurrent administration of DBS (adaptive deep brain stimulation [aDBS] or conventional DBS [cDBS]) and levodopa. (B) The UPDRS III and UDysRS scores during aDBS and cDBS, normalized for the maximum score between aDBS and cDBS. (C) Total electrical energy delivered (TEED) per unit of time (μW) for aDBS (white color) and cDBS (gray color). Error bars represent the standard error (SE). med, medication; stim, stimulation.
See this image and copyright information in PMC

References

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    1. Rosa M, Arlotti M, Ardolino G, et al. Adaptive deep brain stimulation in a freely moving Parkinsonian patient. Mov Disord 2015;30:1003–1005. doi:10.1002/mds.26241 - DOI - PMC - PubMed
    1. Arlotti M, Rosa M, Marceglia S, et al. The adaptive deep brain stimulation challenge. Parkinsonism Relat Disord 2016;28:12–17. doi:10.1016/j.parkreldis.2016.03.020 - DOI - PubMed

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