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Review
. 2017 Feb 16;22(2):299.
doi: 10.3390/molecules22020299.

A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid

Sheng Yu  1 , Hui Yan  2 , Li Zhang  3 , Mingqiu Shan  4   5 , Peidong Chen  6 , Anwei Ding  7 , Sam Fong Yau Li  8
Affiliations
Review

A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid

Sheng Yu et al. Molecules. .

Abstract

Amentoflavone (C30H18O10) is a well-known biflavonoid occurring in many natural plants. This polyphenolic compound has been discovered to have some important bioactivities, including anti-inflammation, anti-oxidation, anti-diabetes, and anti-senescence effects on many important reactions in the cardiovascular and central nervous system, etc. Over 120 plants have been found to contain this bioactive component, such as Selaginellaceae, Cupressaceae, Euphorbiaceae, Podocarpaceae, and Calophyllaceae plant families. This review paper aims to profile amentoflavone on its plant sources, natural derivatives, pharmacology, and pharmacokinetics, and to highlight some existing issues and perspectives in the future.

Keywords: amentoflavone; biflavonoid; natural derivatives; pharmacokinetics; pharmacology; phytochemistry.

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Conflict of interest statement

All the authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structure of amentoflavone.
Figure 2
Figure 2
Chemical structures of natural derivatives of amentoflavone in plants.
See this image and copyright information in PMC

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