Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Mar;76(3):377-390.
doi: 10.1016/j.jaad.2016.07.064.

Psoriasis and comorbid diseases: Epidemiology

Junko Takeshita  1 , Sungat Grewal  2 , Sinéad M Langan  3 , Nehal N Mehta  4 , Alexis Ogdie  5 , Abby S Van Voorhees  6 , Joel M Gelfand  7
Affiliations
Review

Psoriasis and comorbid diseases: Epidemiology

Junko Takeshita et al. J Am Acad Dermatol. 2017 Mar.

Abstract

Psoriasis is a common chronic inflammatory disease of the skin that is increasingly being recognized as a systemic inflammatory disorder. Psoriatic arthritis is a well-known comorbidity of psoriasis. A rapidly expanding body of literature in various populations and settings supports additional associations between psoriasis and cardiometabolic diseases, gastrointestinal diseases, kidney disease, malignancy, infection, and mood disorders. The pathogenesis of comorbid disease in patients with psoriasis remains unknown; however, shared inflammatory pathways, cellular mediators, genetic susceptibility, and common risk factors are hypothesized to be contributing elements. As additional psoriasis comorbidities continue to emerge, education of health care providers is essential to ensuring comprehensive medical care for patients with psoriasis.

Keywords: Crohn's disease; cardiovascular disease; chronic kidney disease; comorbidities; depression; infection; lymphoma; metabolic syndrome; nonalcoholic fatty liver disease; psoriasis; psoriatic arthritis.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: Dr. Takeshita receives a research grant (to the Trusteees of the University of Pennyslvania) from Pfizer and payment for continuing medical education work related to psoriasis. Dr. Mehta is a full time U.S. Government employee. Dr. Ogdie receives research grants from AbbVie (to the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis [GRAPPA]), Celgene (to GRAPPA), and Pfizer Inc. (to the Trustees of the University of Pennsylvania and GRAPPA), and has served as a consultant for Novartis, receiving honoraria. Dr. Van Voorhees has served as a consultant for AbbVie, Amgen, Aqua, Astra Zeneca, Celgene, Corrona, Dermira, Janssen, Leo, Novartis, and Pfizer, receiving honoraria; received a research grant from AbbVie; and has other relationship with Merck. Dr. Gelfand has served as a consultant for AbbVie, AstraZeneca, Celgene Corp, Coherus, Eli Lilly, Janssen Biologics (formerly Centocor), Sanofi, Merck, Novartis Corp, Endo, and Pfizer Inc., receiving honoraria; and receives research grants (to the Trustees of the University of Pennsylvania) from AbbVie, Amgen, Eli Lilly, Janssen, Novartis Corp, Regeneron, and Pfizer Inc.; and received payment for continuing medical education work related to psoriasis. Dr. Gelfand is a co-patent holder of resiquimod for treatment of cutaneous T cell lymphoma.

References

    1. National Psoraisis Foundation. [Accessed October 1, 2015]; https://www.psoriasis.org/cure_known_statistics.
    1. Kurd SK, Gelfand JM. The prevalence of previously diagnosed and undiagnosed psoriasis in US adults: results from NHANES 2003–2004. J Am Acad Dermatol. 2009;60(2):218–224. - PMC - PubMed
    1. Rachakonda TD, Schupp CW, Armstrong AW. Psoriasis prevalence among adults in the United States. J Am Acad Dermatol. 2014;70(3):512–516. - PubMed
    1. Rapp SR, Feldman SR, Exum ML, et al. Psoriasis causes as much disability as other major medical diseases. J Am Acad Dermatol. 1999;41(3 Pt 1):401–407. - PubMed
    1. Strauss H. Zur Lehre von der neurogenen und der thyreogenen Glykosurie. Dtsch Med Wochenschr. 1897;20:309–312.

MeSH terms