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Review
. 2017 Jul 5;9(7):a027888.
doi: 10.1101/cshperspect.a027888.

Mechanisms of Cell Polarity-Controlled Epithelial Homeostasis and Immunity in the Intestine

Leon J Klunder  1 , Klaas Nico Faber  2 , Gerard Dijkstra  2 , Sven C D van IJzendoorn  1
Affiliations
Review

Mechanisms of Cell Polarity-Controlled Epithelial Homeostasis and Immunity in the Intestine

Leon J Klunder et al. Cold Spring Harb Perspect Biol. .

Abstract

Intestinal epithelial cell polarity is instrumental to maintain epithelial homeostasis and balance communications between the gut lumen and bodily tissue, thereby controlling the defense against gastrointestinal pathogens and maintenance of immune tolerance to commensal bacteria. In this review, we highlight recent advances with regard to the molecular mechanisms of cell polarity-controlled epithelial homeostasis and immunity in the human intestine.

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Figures

Figure 1.
Figure 1.
Intestinal epithelial cell polarity. (A) Crypt-villus organization of the intestinal epithelial cell monolayer. (B) Detail of the boxed area in panel A, showing the apical, basal, and lateral surface polarity of the individual enterocyte. (C) Detail of the boxed area in panel B, showing the common/apical recycling endosome (CRE) and the apical recycling endosome (ARE) in the individual enterocyte. (D) Detail of the boxed area in panel C, showing a single microvillus and a microvillus-derived vesicle. TJ, Tight junction; AIP, alkaline intestinal phosphatase; ARE, apical recycling endosome; CRE, common recycling endosome.
See this image and copyright information in PMC

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