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Comment
. 2017 Feb 28;114(9):2101-2102.
doi: 10.1073/pnas.1700337114. Epub 2017 Feb 17.

A win-win for women's reproductive health: A nonsteroidal contraceptive and fertoprotective neoadjuvant

Teresa K Woodruff  1
Affiliations
Comment

A win-win for women's reproductive health: A nonsteroidal contraceptive and fertoprotective neoadjuvant

Teresa K Woodruff. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Ovary is organized into developmental zones, with the primordial follicles established at birth in the peripheral cortex region and growing follicles moving toward the less rigid medulla. Once secondary follicles are formed, they supply factors that limit subordinate follicle growth. One of those factors is MIS/AMH and when supplied in a chronic supraphysiological level, the follicle maturation process is blocked. This outcome could inform novel contraceptive development as well as provide a way to limit follicle activation during the time of life-preserving but sterilizing cancer treatment.
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References

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