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. 2017 May;23(5):836-839.
doi: 10.1016/j.bbmt.2017.02.010. Epub 2017 Feb 15.

Impact of Delayed Infusion Time in Umbilical Cord Blood Transplantation

Richard Mitchell  1 , John E Wagner  2 , Claudio Brunstein  3 , Qing Cao  4 , David H McKenna  5 , Michael R Verneris  6
Affiliations

Impact of Delayed Infusion Time in Umbilical Cord Blood Transplantation

Richard Mitchell et al. Biol Blood Marrow Transplant. 2017 May.

Abstract

In umbilical cord blood (UCB) transplantation, UCB units are typically thawed, washed, and infused into the patient as rapidly as possible. In some instances there is a delay in the time from the unit thaw and wash procedure to infusion into the patient. Therefore, we examined the effect of thaw duration time on engraftment outcomes in 567 patients undergoing UCB transplantation. With a range of 32 to 523 minutes, a prolonged thaw duration had no obvious effect on the incidence of neutrophil engraftment or time to recovery. This was true for recipients of single UCB transplantation (incidence: 97% versus 93%, P = .13; time to neutrophil recovery: 21 days versus 21 days, P = .32; and platelet recovery: 79% versus 78%, P = .48), and similar results were observed in double UCB transplantation (time to neutrophil engraftment: 20 days versus 19 days, P = .71). However, there was a trend toward better platelet recovery in recipients of double UCB transplants with prolonged thaw duration (HR, 1.28; P = .06). In conclusion, this study demonstrates prolonged thaw duration has no detrimental effect on engraftment after single or double UCB transplantation.

Keywords: Cord blood; Engraftment; Thaw time.

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Figures

Figure 1
Figure 1
Time to neutrophil engraftment for (a) single and (b) double UCB transplants. Note that patients with graft failure were excluded from the double UCB analysis.
Figure 2
Figure 2
Platelet engraftment at 1 year for (a) single and (b) double UCB transplants.
Figure 3
Figure 3
Transplant Related Mortality at 1 year for (a) single and (b) double UCB transplants.
See this image and copyright information in PMC

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