Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Sep 11;15(17):7067-79.
doi: 10.1093/nar/15.17.7067.

Potential secondary and tertiary structure in the genomic RNA of foot and mouth disease virus

B E Clarke  1 , A L Brown, K M Currey, S E Newton, D J Rowlands, A R Carroll
Affiliations
Free PMC article

Potential secondary and tertiary structure in the genomic RNA of foot and mouth disease virus

B E Clarke et al. Nucleic Acids Res. .
Free PMC article

Abstract

The nucleotide sequence of the 5' untranslated region of foot and mouth disease virus (FMDV), serotype A10 has been determined. This completes the first total genomic sequence for any one serotype of FMDV. Analysis of the sequence to the 3' side of the poly (C) tract reveals the presence of a 24 nucleotide repeated motif which has homologies with a sequence located upstream of the transcriptional initiation site from several mammalian fibrinogen genes. The function of this element in FMDV is unclear. However, computer analysis of this region predicts the presence of a high degree of secondary and tertiary structure in which these repeats form an important part. The implications of these predictions are discussed.

PubMed Disclaimer

References

    1. Cell. 1985 Mar;40(3):515-26 - PubMed
    1. Nucleic Acids Res. 1984 Aug 24;12(16):6587-601 - PubMed
    1. J Virol. 1985 Jun;54(3):651-60 - PubMed
    1. Nucleic Acids Res. 1985 Mar 11;13(5):1717-31 - PubMed
    1. J Gen Virol. 1985 Sep;66 ( Pt 9):1919-29 - PubMed