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Review
. 2017 Mar-Apr;83(2):215-227.
doi: 10.1016/j.bjorl.2017.01.002. Epub 2017 Jan 21.

Position statement of the Brazilian Academy of Rhinology on the use of antihistamines, antileukotrienes, and oral corticosteroids in the treatment of inflammatory sinonasal diseases

Olavo de Godoy Mion  1 , João Ferreira de Mello Jr  2 , Daniel Lorena Dutra  3 , Nilvano Alves de Andrade  3 , Washington Luiz de Cerqueira Almeida  3 , Wilma Teresinha Anselmo-Lima  4 , Leonardo Lopes Balsalobre Filho  5 , Jair de Carvalho E Castro  6 , Roberto Eustáquio Dos Santos Guimarães  7 , Marcus Miranda Lessa  8 , Sérgio Fabrício Maniglia  9 , Roberto Campos Meireles  10 , Márcio Nakanishi  11 , Shirley Shizue Nagata Pignatari  12 , Renato Roithmann  13 , Fabrizio Ricci Romano  14 , Rodrigo de Paula Santos  6 , Marco César Jorge Dos Santos  3 , Edwin Tamashiro  15
Affiliations
Review

Position statement of the Brazilian Academy of Rhinology on the use of antihistamines, antileukotrienes, and oral corticosteroids in the treatment of inflammatory sinonasal diseases

Olavo de Godoy Mion et al. Braz J Otorhinolaryngol. 2017 Mar-Apr.

Abstract
in English, Portuguese

Introduction: Inflammatory conditions of the nose and paranasal sinuses are very prevalent in the general population, resulting in marked loss of quality of life in affected patients, as well as significant work, leisure, and social activity losses. These patients require specific and specialized treatment. A wide range of oral medications are available.

Objective: The present document is aimed to clarify, for professionals treating patients with inflammatory sinonasal diseases, both specialists and general practitioners, specific oral therapies in noninfectious nasal inflammatory conditions.

Methods: The methodology used to create this article included the search for the key words: oral corticosteroids, antihistamines, antileukotrienes, rhinitis, rhinosinusitis in the MEDLINE and EMBASE databases in the last 5 years. Since no relevant article was found for the text on the subject of interest in the last 5 years, the search was extended for another 5 years, and so on, according to the authors' needs.

Results: Relevant literature was found regarding the use of antihistamines, antileukotrienes and oral corticosteroids in these conditions. The Brazilian Academy of Rhinology emphasizes, after extensive discussion by the collegiate, key points in the treatment with these drugs.

Conclusion: There is support in the literature for the use of these drugs; however, final considerations about the role of each of them have been made.

Introdução: As afecções inflamatórias do nariz e seios paranasais são muito prevalentes na população geral, causam acentuada perda de qualidade de vida dos pacientes afetados, gerando perdas significativas das atividades de trabalho, lazer e sociais. Estes pacientes necessitam de tratamento específico e especializado e uma ampla gama de medicações orais estão disponíveis.

Objetivo: O presente documento tem por objetivo esclarecer àqueles que tratam das doenças nasossinusais inflamatórias, tanto especialistas quanto generalistas, sobre as terapêuticas orais nas afecções inflamatórias nasais não infecciosas.

Método: A metodologia utilizada para elaboração deste artigo incluiu a busca das palavras chave: corticosteroides orais, anti-histamínicos, antileucotrienos, rinite, rinossinusite nos bancos de dados MEDLINE e EMBASE nos últimos 5 anos. Não sendo encontrado artigo relevante para o texto sobre o assunto de interesse nos últimos 5 anos, a busca poi extendida por mais 5 anos, e assim por diante, de acordo com a necessidade dos autores.

Resultados: Literatura relevante foi encontrada com relação ao uso dos anti-histamínicos, antileucotrienos e corticosteroides orais nestas afecções. A Academia Brasileira de Rinologia resalta, após amplo debate do colegiado, pontos-chave no tratamento com estes medicamentos.

Conclusão: Há respaldo na literatura para o uso destes medicamentos, entretanto considerações finais acerca do papel de cada deles foram feitas.

Keywords: Antagonistas de leucotrieno; Anti-histamínicos; Antihistamines; Glicocorticoides; Glucocorticoids; Leukotriene antagonists; Rhinitis; Rhinosinusitis; Rinites; Rinossinusites.

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Figures

Figure 1
Figure 1
Eicosanoid pathway leading to leukotriene formation.
See this image and copyright information in PMC

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