Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Dec 30:10:836-848.
doi: 10.2174/1874325001610010836. eCollection 2016.

An update on the Application of Nanotechnology in Bone Tissue Engineering

M F Griffin  1 , D M Kalaskar  1 , A Seifalian  1 , P E Butler  1
Affiliations

An update on the Application of Nanotechnology in Bone Tissue Engineering

M F Griffin et al. Open Orthop J. .

Abstract

Background: Natural bone is a complex and hierarchical structure. Bone possesses an extracellular matrix that has a precise nano-sized environment to encourage osteoblasts to lay down bone by directing them through physical and chemical cues. For bone tissue regeneration, it is crucial for the scaffolds to mimic the native bone structure. Nanomaterials, with features on the nanoscale have shown the ability to provide the appropriate matrix environment to guide cell adhesion, migration and differentiation.

Methods: This review summarises the new developments in bone tissue engineering using nanobiomaterials. The design and selection of fabrication methods and biomaterial types for bone tissue engineering will be reviewed. The interactions of cells with different nanostructured scaffolds will be discussed including nanocomposites, nanofibres and nanoparticles.

Results: Several composite nanomaterials have been able to mimic the architecture of natural bone. Bioceramics biomaterials have shown to be very useful biomaterials for bone tissue engineering as they have osteoconductive and osteoinductive properties. Nanofibrous scaffolds have the ability to provide the appropriate matrix environment as they can mimic the extracellular matrix structure of bone. Nanoparticles have been used to deliver bioactive molecules and label and track stem cells.

Conclusion: Future studies to improve the application of nanomaterials for bone tissue engineering are needed.

Keywords: Bioceramics; Bone regeneration; Bone tissue engineering; Composite; Nanofibres; Nanoparticles.

PubMed Disclaimer

Figures

Fig. (1)
Fig. (1)
Fig. (2)
Fig. (2)
Fig. (3)
Fig. (3)
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Khalili A.A., Ahmad M.R. A review of cell adhesion studies for biomedical and biological applications. Int. J. Mol. Sci. 2015;16(8):18149–18184. doi: 10.3390/ijms160818149. - DOI - PMC - PubMed
    1. Rosa N., Simoes R., Magalhães F.D., Marques A.T. From mechanical stimulus to bone formation: A review. Med. Eng. Phys. 2015;37(8):719–728. doi: 10.1016/j.medengphy.2015.05.015. - DOI - PubMed
    1. Venkatesan J, Kim SK. Nano-hydroxyapatite composite biomaterials for bone tissue engineering--a review. J. Biomed. Nanotechnol. 2014;10:3124–40. - PubMed
    1. Venkatesan J., Bhatnagar I., Manivasagan P., Kang K.H., Kim S.K. Alginate composites for bone tissue engineering: a review. Int. J. Biol. Macromol. 2015;72:269–281. doi: 10.1016/j.ijbiomac.2014.07.008. - DOI - PubMed
    1. Sun L., Stout D.A., Webster T.J. The nano-effect: improving the long-term prognosis for musculoskeletal implants. J. Long Term Eff. Med. Implants. 2012;22(3):195–209. doi: 10.1615/JLongTermEffMedImplants.2013006216. - DOI - PubMed

LinkOut - more resources