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Review
. 2016 Dec 30;6(4):219-222.
doi: 10.4103/2045-9912.196904. eCollection 2016 Oct-Dec.

Molecular hydrogen: a therapeutic antioxidant and beyond

Lei Huang  1
Affiliations
Review

Molecular hydrogen: a therapeutic antioxidant and beyond

Lei Huang. Med Gas Res. .

Abstract

Molecular hydrogen (H2) medicine research has flourished since a landmark publication in Nature Medicine that revealed the antioxidant and cytoprotective effects of hydrogen gas in a focal stroke model. Emerging evidence has consistently demonstrated that molecular hydrogen is a promising therapeutic option for a variety of diseases and the underlying comprehensive mechanisms is beyond pure hydroxyl radicals scavenging. The non-toxicity at high concentrations and rapid cellular diffusion features of molecular hydrogen ensure the feasibility and readiness of its clinical translation to human patients.

Keywords: anti-apoptosis; anti-inflammation; biological effect; clinical application; free radical scavenger; hydrogen gas; hydrogen-oxygen nebulizer machine; hydrogen-saturated water/saline.

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Conflict of interest statement

Conflicts of interest None.

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