Effect of oral versus intramuscular Vitamin D replacement in apparently healthy adults with Vitamin D deficiency
- PMID: 28217512
- PMCID: PMC5240054
- DOI: 10.4103/2230-8210.196007
Effect of oral versus intramuscular Vitamin D replacement in apparently healthy adults with Vitamin D deficiency
Abstract
Context: A number of controversies exist regarding appropriate treatment strategy for Vitamin D deficiency.
Aims: The aim of this study was to investigate the efficacy of equivalent doses of oral cholecalciferol (60,000 IU weekly for 5 weeks) versus intramuscular (IM) cholecalciferol (300,000 IU) in correcting Vitamin D deficiency in apparently healthy volunteers working in a hospital.
Settings and design: Prospective randomized open-label single institution study.
Subjects and methods: This study enrolled 40 apparently healthy adults with Vitamin D deficiency into 2 arms. The oral cholecalciferol group (n = 20) received oral cholecalciferol 60,000 IU weekly for 5 weeks while the IM cholecalciferol group (n = 20) received a single injection of cholecalciferol 300,000 IU. The main outcome measure was serum 25-hydroxyvitamin D (25OHD) levels at baseline, 6 and 12 weeks after the intervention.
Statistical analysis used: Differences in serum 25OHD and other biochemical parameters at baseline and follow-up were analyzed using general linear model.
Results: Mean 25OHD level at baseline was 5.99 ± 1.07 ng/mL and 7.40 ± 1.13 ng/mL (P = 0.332) in the oral cholecalciferol and IM cholecalciferol group, respectively. In the oral cholecalciferol group, serum 25OHD level was 20.20 ± 1.65 ng/mL at 6 weeks and 16.66 ± 1.36 ng/mL at 12 weeks. The corresponding serum 25OHD levels in the IM cholecalciferol group were 20.74 ± 1.81 ng/mL and 25.46 ± 1.37 ng/mL at 6 and 12 weeks, respectively. At 12 weeks, the mean 25OHD levels in IM cholecalciferol group was higher as compared to the oral cholecalciferol group (25.46 ± 1.37 vs. 16.66 ± 1.36 ng/mL; P < 0.001).
Conclusions: Both oral and IM routes are effective for the treatment of Vitamin D deficiency. 25-hydroxyvitamin D levels in the IM cholecalciferol group showed a sustained increase from baseline.
Keywords: Intramuscular cholecalciferol; Vitamin D deficiency; Vitamin D replacement; oral cholecalciferol.
Conflict of interest statement
There are no conflicts of interest.
Figures



Similar articles
-
Efficacy and safety of high dose intramuscular or oral cholecalciferol in vitamin D deficient/insufficient elderly.Maturitas. 2012 Aug;72(4):332-8. doi: 10.1016/j.maturitas.2012.04.011. Epub 2012 May 20. Maturitas. 2012. PMID: 22613271 Clinical Trial.
-
Effect of oral cholecalciferol 2,000 versus 5,000 IU on serum vitamin D, PTH, bone and muscle strength in patients with vitamin D deficiency.Osteoporos Int. 2013 Mar;24(3):1101-5. doi: 10.1007/s00198-012-1944-7. Epub 2012 Mar 16. Osteoporos Int. 2013. PMID: 22422304 Clinical Trial.
-
Vitamin D levels in IBD: a randomised trial of weight-based versus fixed dose vitamin D supplementation.Scand J Gastroenterol. 2020 Jun;55(6):671-676. doi: 10.1080/00365521.2020.1774921. Epub 2020 Jun 13. Scand J Gastroenterol. 2020. PMID: 32538182 Clinical Trial.
-
Is calcifediol better than cholecalciferol for vitamin D supplementation?Osteoporos Int. 2018 Aug;29(8):1697-1711. doi: 10.1007/s00198-018-4520-y. Epub 2018 Apr 30. Osteoporos Int. 2018. PMID: 29713796 Review.
-
Vitamin D supplementation for sickle cell disease.Cochrane Database Syst Rev. 2020 May 28;5(5):CD010858. doi: 10.1002/14651858.CD010858.pub3. Cochrane Database Syst Rev. 2020. PMID: 32462740 Free PMC article.
Cited by
-
A Critical Appraisal of Strategies to Optimize Vitamin D Status in Germany, a Population with a Western Diet.Nutrients. 2019 Nov 6;11(11):2682. doi: 10.3390/nu11112682. Nutrients. 2019. PMID: 31698703 Free PMC article.
-
Clinical Practice in the Prevention, Diagnosis and Treatment of Vitamin D Deficiency: A Central and Eastern European Expert Consensus Statement.Nutrients. 2022 Apr 2;14(7):1483. doi: 10.3390/nu14071483. Nutrients. 2022. PMID: 35406098 Free PMC article. Review.
-
The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musculoskeletal Pain.Nutrients. 2022 Jul 22;14(15):3010. doi: 10.3390/nu14153010. Nutrients. 2022. PMID: 35893864 Free PMC article.
-
Vitamin D Is Associated with Clinical Outcomes in Patients with Primary Biliary Cholangitis.Nutrients. 2022 Feb 19;14(4):878. doi: 10.3390/nu14040878. Nutrients. 2022. PMID: 35215528 Free PMC article.
-
Glucocorticoid-induced Osteoporosis.Indian J Endocrinol Metab. 2017 Sep-Oct;21(5):652-654. doi: 10.4103/ijem.IJEM_187_17. Indian J Endocrinol Metab. 2017. PMID: 28989868 Free PMC article. No abstract available.
References
-
- Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, et al. Global Vitamin D status and determinants of hypovitaminosis D. Osteoporos Int. 2009;20:1807–20. - PubMed
-
- Arya V, Bhambri R, Godbole MM, Mithal A. Vitamin D status and its relationship with bone mineral density in healthy Asian Indians. Osteoporos Int. 2004;15:56–61. - PubMed
-
- Sachan A, Gupta R, Das V, Agarwal A, Awasthi PK, Bhatia V. High prevalence of Vitamin D deficiency among pregnant women and their newborns in Northern India. Am J Clin Nutr. 2005;81:1060–4. - PubMed
-
- Marwaha RK, Tandon N, Reddy DR, Aggarwal R, Singh R, Sawhney RC, et al. Vitamin D and bone mineral density status of healthy schoolchildren in Northern India. Am J Clin Nutr. 2005;82:477–82. - PubMed
-
- Harinarayan CV. Prevalence of Vitamin D insufficiency in postmenopausal South Indian women. Osteoporos Int. 2005;16:397–402. - PubMed
LinkOut - more resources
Full Text Sources
Other Literature Sources