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. 2017 Jan;60(1):100-105.
doi: 10.5468/ogs.2017.60.1.100. Epub 2017 Jan 15.

Effect of calcium on premenstrual syndrome: A double-blind randomized clinical trial

Fatemeh Shobeiri  1 , Fahimeh Ezzati Araste  1 , Reihaneh Ebrahimi  1 , Ensiyeh Jenabi  2 , Mansour Nazari  3
Affiliations

Effect of calcium on premenstrual syndrome: A double-blind randomized clinical trial

Fatemeh Shobeiri et al. Obstet Gynecol Sci. 2017 Jan.

Abstract

Objective: Premenstrual syndrome (PMS) affects millions of women and is known as the most important disorder among them. The very aim of the present study was to evaluate the effects of low dose calcium on severity of PMS.

Methods: This study can be considered as a double-blind randomized clinical trial. Female students of Hamadan University of Medical Sciences diagnosed with PMS in 2014 participated in the present study. Sixty-six female students diagnosed with PMS were involved in the experimental and control groups. The participants were randomly assigned into two groups to receive 500 mg of calcium daily or placebo for two months. Severity of PMS was detected by Daily Record of Severity of Problems, which was used to measure symptoms during one menstrual cycle before and two menstrual cycles after the intervention.

Results: No signifcant differences were observed in the mean scores of PMS symptoms between calcium and placebo groups before the treatment (P=0.74). However, signifcant differences were noticed between the two intervention groups in the first (P=0.01) and second menstrual cycles (P=0.001) after the intervention. The differences were significant in subgroups of anxiety, depression, emotional changes, water retention, and somatic changes in calcium group compared with placebo group in the menstrual cycle before the intervention and two menstrual cycles after the intervention and among menstrual cycles (0, cycle 1, cycle 2) in calcium group (P=0.01).

Conclusion: Overall, the results of the present study suggest that treatment with calcium supplements is an effective method for reducing mood disorders during PMS.

Keywords: Calcium; Premenstrual syndrome; Randomized clinical trial.

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Conflict of interest statement

Conflict of interest: No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1. Flowchart of progress through the trial.
See this image and copyright information in PMC

References

    1. Fathizadeh N, Ebrahimi E, Valiani M, Tavakoli N, Yar MH. Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome. Iran J Nurs Midwifery Res. 2010;15(Suppl 1):401–405. - PMC - PubMed
    1. Khajehei M, Abdali K, Parsanezhad ME, Tabatabaee HR. Effect of treatment with dydrogesterone or calcium plus vitamin D on the severity of premenstrual syndrome. Int J Gynaecol Obstet. 2009;105:158–161. - PubMed
    1. Thys-Jacobs S, Starkey P, Bernstein D, Tian J. Calcium carbonate and the premenstrual syndrome: effects on premenstrual and menstrual symptoms. Premenstrual Syndrome Study Group. Am J Obstet Gynecol. 1998;179:444–452. - PubMed
    1. Ghanbari Z, Haghollahi F, Shariat M, Foroshani AR, Ashrafi M. Effects of calcium supplement therapy in women with premenstrual syndrome. Taiwan J Obstet Gynecol. 2009;48:124–129. - PubMed
    1. Freeman EW. Therapeutic management of premenstrual syndrome. Expert Opin Pharmacother. 2010;11:2879–2889. - PubMed