Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2017 Jan;60(1):133-137.
doi: 10.5468/ogs.2017.60.1.133. Epub 2017 Jan 19.

Pregnancy-related osteoporosis and spinal fractures

Ka Yeong Yun  1 , Si Eun Han  1 , Seung Chul Kim  1 , Jong Kil Joo  2 , Kyu Sup Lee  1
Affiliations
Case Reports

Pregnancy-related osteoporosis and spinal fractures

Ka Yeong Yun et al. Obstet Gynecol Sci. 2017 Jan.

Abstract

Pregnancy-related osteoporosis is a very rare condition characterized by the occurrence of fracture during pregnancy or the puerperium. Despite its relative rarity, it can be a dangerous condition that causes severe back pain, height loss and disability. Normal physiologic changes during pregnancy, genetic or racial difference, obstetrical history and obstetrical disease, such as preterm labor or pregnancy-induced hypertension, are presumed risk factors of pregnancy-related osteooporosis. However, exact etiology and pathogenesis are uncertain. The management and natural history are still poorly defined. Traditional medications for osteoporosis are calcium/vitamin D and bisphosphonate. Concerns with bisphosphonate include accumulation in bone and fetal exposure in subsequent pregnancies. The newly developed medication, teriparatide, has shown good results. We report six cases of pregnancy-related osteoporosis and spinal fracture with literature review.

Keywords: Fractures; Osteoporosis; Pregnancy; compression.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1. (A,B) Vertebral compression fractures in magnetic resonance imaging in case 3.
See this image and copyright information in PMC

References

    1. Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S, et al. Clinician's guide to prevention and treatment of osteoporosis. Osteoporos Int. 2014;25:2359–2381. - PMC - PubMed
    1. Kim TH, Lee HH, Jeon DS, Byun DW. Compression fracture in postpartum osteoporosis. J Bone Metab. 2013;20:115–118. - PMC - PubMed
    1. Lebel E, Mishukov Y, Babchenko L, Samueloff A, Zimran A, Elstein D. Bone mineral density in gravida: effect of pregnancies and breast-feeding in women of differing ages and parity. J Osteoporos. 2014;2014:897182. - PMC - PubMed
    1. Polat SB, Evranos B, Aydin C, Cuhaci N, Ersoy R, Cakir B. Effective treatment of severe pregnancy and lactation-related osteoporosis with teriparatide: case report and review of the literature. Gynecol Endocrinol. 2015;31:522–525. - PubMed
    1. Holmberg-Marttila D, Sievanen H, Tuimala R. Changes in bone mineral density during pregnancy and postpartum: prospective data on five women. Osteoporos Int. 1999;10:41–46. - PubMed

Publication types