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Editorial
. 2017 Jan 18:4:3.
doi: 10.21037/sci.2016.12.04. eCollection 2017.

MED12 in hematopoietic stem cells-cell specific function despite ubiquitous expression

Maria-Cristina Keightley  1 , Susan K Nilsson  2 , Graham J Lieschke  1
Affiliations
Editorial

MED12 in hematopoietic stem cells-cell specific function despite ubiquitous expression

Maria-Cristina Keightley et al. Stem Cell Investig. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Comment on

  • MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.
    Aranda-Orgilles B, Saldaña-Meyer R, Wang E, Trompouki E, Fassl A, Lau S, Mullenders J, Rocha PP, Raviram R, Guillamot M, Sánchez-Díaz M, Wang K, Kayembe C, Zhang N, Amoasii L, Choudhuri A, Skok JA, Schober M, Reinberg D, Sicinski P, Schrewe H, Tsirigos A, Zon LI, Aifantis I. Aranda-Orgilles B, et al. Cell Stem Cell. 2016 Dec 1;19(6):784-799. doi: 10.1016/j.stem.2016.08.004. Epub 2016 Aug 25. Cell Stem Cell. 2016. PMID: 27570068 Free PMC article.

References

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    1. Schwartz CE, Tarpey PS, Lubs HA, et al. The original Lujan syndrome family has a novel missense mutation (p.N1007S) in the MED12 gene. J Med Genet 2007;44:472-7. 10.1136/jmg.2006.048637 - DOI - PMC - PubMed
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    1. Vulto-van Silfhout AT, de Vries BB, van Bon BW, et al. Mutations in MED12 cause X-linked Ohdo syndrome. Am J Hum Genet 2013;92:401-6. 10.1016/j.ajhg.2013.01.007 - DOI - PMC - PubMed
    1. Mäkinen N, Mehine M, Tolvanen J, et al. MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas. Science 2011;334:252-5. 10.1126/science.1208930 - DOI - PubMed

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