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Comparative Study
. 1987 Jul;31(7):1135-6.
doi: 10.1128/AAC.31.7.1135.

Treatment of Clostridium difficile colitis in hamsters with a lipopeptide antibiotic, LY146032

M Y Dong  1 , T W Chang, S L Gorbach
Affiliations
Comparative Study

Treatment of Clostridium difficile colitis in hamsters with a lipopeptide antibiotic, LY146032

M Y Dong et al. Antimicrob Agents Chemother. 1987 Jul.

Abstract

LY146032, an acidic lipopeptide antibiotic which inhibits the biosynthesis of cell wall peptidoglycan, was found to be effective in delaying death in a hamster model of pseudomembranous colitis. A dose of 0.05 mg/day was effective. The equivalent protection with vancomycin required a dose 100-fold higher, i.e., 5 mg/day.

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References

    1. Johns Hopkins Med J. 1977 Oct;141(4):183-92 - PubMed
    1. Antimicrob Agents Chemother. 1987 Mar;31(3):461-2 - PubMed
    1. Infect Immun. 1978 Nov;22(2):418-22 - PubMed
    1. J Infect Dis. 1977 Nov;136(5):701-5 - PubMed

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