[Function and modulation of type Ⅱ innate lymphoid cells and their role in chronic upper airway inflammatory diseases]
- PMID: 28219179
- DOI: 10.3760/cma.j.issn.1673-0860.2017.02.017
[Function and modulation of type Ⅱ innate lymphoid cells and their role in chronic upper airway inflammatory diseases]
Abstract
Type Ⅱ innate lymphoid cells (ILC2) is a family of innate immune lymphocytes, which provide effective immune responses to cytokines. ILC2 are regulated by the nuclear transcription factor ROR alpha and GATA3, secreting cytokines IL-5 and IL-13, etc. Animal models have shown that ILC2 are involved in allergic diseases, such as asthma and atopic dermatitis, and also play a very important role in the metabolic balance. In addition, recent reports suggest that ILC2 not only play a role in the initial stages of the disease, but also can lead to chronic pathological changes in the disease, such as fibrosis, and may have an effect on acquired immunity. This paper mainly focus in the role and regulation of ILC2 cells, and review the research status of ILC2 in the field of chronic upper airway inflammatory diseases including allergic rhinitis and chronic rhinosinusitis.
Ⅱ型固有淋巴细胞(typeⅡinnate lymphoid cells，ILC2)属于天然免疫淋巴细胞家族的一个成员，它可以提供有效的免疫效应细胞因子，从而启动后续的免疫反应。ILC2受核转录因子RORα和GATA3的调控，分泌细胞因子白细胞介素(IL)5和IL-13等。动物实验模型证明，ILC2参与了变态反应性疾病，如哮喘和变应性皮炎，而且在代谢平衡中扮演了十分重要的角色。此外，最近的研究表明，ILC2不仅在疾病的初始阶段发挥作用，也可以导致疾病的慢性病理改变，如纤维化等，并可对获得性免疫产生影响。本文主要对ILC2细胞的作用、调控及其在变应性鼻炎(AR)和慢性鼻-鼻窦炎(CRS)等慢性上呼吸道炎性疾病中的研究现状进行综述。.
Keywords: Asthma; Rhinitis; Sinusitis; Type2 innate lymphoid cells.
Similar articles
-
Innate lymphoid type 2 cells in chronic rhinosinusitis.Curr Opin Allergy Clin Immunol. 2016 Feb;16(1):7-12. doi: 10.1097/ACI.0000000000000229. Curr Opin Allergy Clin Immunol. 2016. PMID: 26600260 Review.
-
Type-2 innate lymphoid cells in asthma and allergy.Ann Am Thorac Soc. 2014 Dec;11 Suppl 5(Suppl 5):S263-70. doi: 10.1513/AnnalsATS.201403-097AW. Ann Am Thorac Soc. 2014. PMID: 25525730 Free PMC article. Review.
-
[Type 2 innate lymphoid cells and chronic rhinosinusitis].Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Apr 5;30(7):585-588. doi: 10.13201/j.issn.1001-1781.2016.07.025. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016. PMID: 29871081 Review. Chinese.
-
Role of Superantigens in Allergic Inflammation: Their Relationship to Allergic Rhinitis, Chronic Rhinosinusitis, Asthma, and Atopic Dermatitis.Am J Rhinol Allergy. 2018 Nov;32(6):502-517. doi: 10.1177/1945892418801083. Epub 2018 Sep 25. Am J Rhinol Allergy. 2018. PMID: 30253652 Review.
-
Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells.Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10240-5. doi: 10.1073/pnas.1217158110. Epub 2013 Jun 3. Proc Natl Acad Sci U S A. 2013. PMID: 23733962 Free PMC article.
Cited by
-
Role of autophagy and mitophagy of group 2 innate lymphoid cells in allergic and local allergic rhinitis.World Allergy Organ J. 2024 Jan 17;17(2):100852. doi: 10.1016/j.waojou.2023.100852. eCollection 2024 Feb. World Allergy Organ J. 2024. PMID: 38298830 Free PMC article.
