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. 1987 Jun 1;244(2):465-9.
doi: 10.1042/bj2440465.

Renal dipeptidase is one of the membrane proteins released by phosphatidylinositol-specific phospholipase C

N M Hooper  1 , M G Low, A J Turner
Affiliations

Renal dipeptidase is one of the membrane proteins released by phosphatidylinositol-specific phospholipase C

N M Hooper et al. Biochem J. .

Abstract

Renal dipeptidase (dehydropeptidase-I, EC 3.4.13.11) was released from pig kidney membrane preparations by treatment with phosphatidylinositol-specific phospholipase C from Staphylococcus aureus and Bacillus thuringiensis and a phospholipase C preparation from Bacillus cereus to a similar extent as alkaline phosphatase. Endopeptidase-24.11 and aminopeptidase N were not released by this treatment. After treatment of the membrane fraction with the S. aureus phospholipase C the dipeptidase was converted from an amphipathic to a hydrophilic form, as deduced from phase-separation experiments in Triton X-114. It is concluded that renal dipeptidase is anchored to the microvillar membrane by covalently attached phosphatidylinositol.

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References

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