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Comment
. 2017 Mar;27(3):313-314.
doi: 10.1038/cr.2017.21. Epub 2017 Feb 21.

New CRISPR-Cas systems discovered

Hui Yang  1 , Dinshaw J Patel  1
Affiliations
Comment

New CRISPR-Cas systems discovered

Hui Yang et al. Cell Res. 2017 Mar.

Abstract

In bacteria and archaea, CRISPR-Cas adaptive immune systems utilize RNA-guided endonucleases to defend against invasion by foreign nucleic acids of bacteriophage, virus and plasmid origin. In a recent paper published in Nature, Burstein et al. identified the first Cas9 protein in uncultivated archaea and two novel CRISPR-CasX and CRISPR-CasY systems in uncultivated bacteria by capitalizing on analysis of terabase-scale metagenomic datasets from natural uncultivated organisms.

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Comment on

  • New CRISPR-Cas systems from uncultivated microbes.
    Burstein D, Harrington LB, Strutt SC, Probst AJ, Anantharaman K, Thomas BC, Doudna JA, Banfield JF. Burstein D, et al. Nature. 2017 Feb 9;542(7640):237-241. doi: 10.1038/nature21059. Epub 2016 Dec 22. Nature. 2017. PMID: 28005056 Free PMC article.

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