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. 2017 Feb;45(1):290-302.
doi: 10.1177/0300060516676725. Epub 2017 Jan 12.

Autologous stem cell transplantation as frontline strategy for peripheral T-cell lymphoma: A single-centre experience

Xiao Han  1 , Wei Zhang  1 , Daobin Zhou  1 , Jing Ruan  1 , Minghui Duan  1 , Tienan Zhu  1 , Jian Li  1 , Huacong Cai  1 , Xinxin Cao  1 , Mingqi Ouyang  1
Affiliations

Autologous stem cell transplantation as frontline strategy for peripheral T-cell lymphoma: A single-centre experience

Xiao Han et al. J Int Med Res. 2017 Feb.

Abstract

Objective To determine the efficacy and prognosis of autologous hematopoietic stem cell transplantation (ASCT) as frontline treatment for peripheral T cell lymphoma (PTCL). Methods Clinical data from 46 PTCL patients who achieved complete (CR) or partial remission (PR) after ASCT from October 1996 to July 2014 were analysed retrospectively. Results Median patient age was 32 (range: 15-68) years. Disease types included PTCL, unspecified type, in 23 patients, anaplastic large cell lymphoma in eight, angioimmunoblastic lymphoma in eight, extranodal NK/T-cell lymphoma in five, and hepatosplenic T-cell lymphoma and enteropathy associated T-cell lymphoma in one each. Of these patients, 80% had Prognostic Index for Peripheral T-cell Lymphoma scores ≥1. Thirty-four patients had pre-transplantation CR and 12 had PR. Median follow up was 37 (6-176) months. The 5-year overall survival (OS) and progression-free survival (PFS) rates were 77.1% and 61.9%, respectively. Multivariate analysis showed that pre-transplantation CR was an independent risk factor for survival, and CR was more common than PR (OS 81% vs 59.3%; PFS 71.8% vs 17.8%). Conclusion Frontline consolidation treatment with ASCT was associated with favourable outcomes in patients with PTCL. Pre-transplantation CR was a prognostic factor for survival, suggesting that ASCT may be favoured as front-line consolidation therapy after first complete remission.

Keywords: Autologous stem-cell transplantation; complete response; consolidation; frontline; peripheral T-cell lymphoma.

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Figures

Figure 1.
Figure 1.
Overall and progression-free survival from diagnosis in peripheral T cell lymphoma patients who achieved complete (CR) or partial remission (PR) after autologous stem cell transplantation (ASCT).
Figure 2.
Figure 2.
Survival according to pre-transplant response for the 46 peripheral T cell lymphoma patients. Pre-transplant CR achievement was associated with significantly better OS and PFS than pre-transplant PR. CR: complete remission; PR: partial remission; OS: overall survival; PFS: progression free survival.
See this image and copyright information in PMC

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