Microbiome-dependent recombination shapes the host antibody repertoire
- PMID: 28223410
- DOI: 10.1126/scisignal.aan0005
Microbiome-dependent recombination shapes the host antibody repertoire
Abstract
Secreted IgD concentration depends on the presence of microbiota.
Copyright © 2017, American Association for the Advancement of Science.
Comment on
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IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice.Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1196-E1204. doi: 10.1073/pnas.1621258114. Epub 2017 Jan 30. Proc Natl Acad Sci U S A. 2017. PMID: 28137874 Free PMC article.
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