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Comment
. 2017 Feb 21;10(467):eaam9984.
doi: 10.1126/scisignal.aam9984.

Papers of note in Nature542 (7641)

Annalisa M VanHook  1
Affiliations
Comment

Papers of note in Nature542 (7641)

Annalisa M VanHook. Sci Signal. .

Abstract

This week's articles highlight a tRNA synthetase in mTORC1 signaling in fat cell metabolism and aging, the vulnerability of cancer cells to drugs that target proteostasis, and a mechanism by which stressed neurons expel protein aggregates and dysfunctional organelles.

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Comment on

  • Physiology: An atypical switch for metabolism and ageing.
    Selman C, Withers DJ. Selman C, et al. Nature. 2017 Feb 16;542(7641):299-300. doi: 10.1038/nature21500. Epub 2017 Feb 8. Nature. 2017. PMID: 28178230 Free PMC article.
  • Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.
    Genovese G, Carugo A, Tepper J, Robinson FS, Li L, Svelto M, Nezi L, Corti D, Minelli R, Pettazzoni P, Gutschner T, Wu CC, Seth S, Akdemir KC, Leo E, Amin S, Molin MD, Ying H, Kwong LN, Colla S, Takahashi K, Ghosh P, Giuliani V, Muller F, Dey P, Jiang S, Garvey J, Liu CG, Zhang J, Heffernan TP, Toniatti C, Fleming JB, Goggins MG, Wood LD, Sgambato A, Agaimy A, Maitra A, Roberts CW, Wang H, Viale A, DePinho RA, Draetta GF, Chin L. Genovese G, et al. Nature. 2017 Feb 16;542(7641):362-366. doi: 10.1038/nature21064. Epub 2017 Feb 8. Nature. 2017. PMID: 28178232 Free PMC article.
  • EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice.
    Arif A, Terenzi F, Potdar AA, Jia J, Sacks J, China A, Halawani D, Vasu K, Li X, Brown JM, Chen J, Kozma SC, Thomas G, Fox PL. Arif A, et al. Nature. 2017 Feb 16;542(7641):357-361. doi: 10.1038/nature21380. Epub 2017 Feb 8. Nature. 2017. PMID: 28178239 Free PMC article.
  • C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress.
    Melentijevic I, Toth ML, Arnold ML, Guasp RJ, Harinath G, Nguyen KC, Taub D, Parker JA, Neri C, Gabel CV, Hall DH, Driscoll M. Melentijevic I, et al. Nature. 2017 Feb 16;542(7641):367-371. doi: 10.1038/nature21362. Epub 2017 Feb 8. Nature. 2017. PMID: 28178240 Free PMC article.

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