Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Feb 7;23(5):776-791.
doi: 10.3748/wjg.v23.i5.776.

To screen or not to screen? Celiac antibodies in liver diseases

Janaína Luz Narciso-Schiavon  1 , Leonardo Lucca Schiavon  1
Affiliations
Review

To screen or not to screen? Celiac antibodies in liver diseases

Janaína Luz Narciso-Schiavon et al. World J Gastroenterol. .

Abstract

Celiac disease (CD) is a systemic immune-mediated disorder triggered by dietary gluten in genetically predisposed individuals. The typical symptoms are anemia, diarrhea, fatigue, weight loss, and abdominal pain. CD has been reported in patients with primary sclerosing cholangitis, primary biliary cholangitis, autoimmune hepatitis, aminotransferase elevations, nonalcoholic fatty liver disease, hepatitis B, hepatitis C, portal hypertension and liver cirrhosis. We evaluate recommendations for active screening for CD in patients with liver diseases, and the effect of a gluten-free diet in these different settings. Active screening for CD is recommended in patients with liver diseases, particularly in those with autoimmune disorders, steatosis in the absence of metabolic syndrome, noncirrhotic intrahepatic portal hypertension, cryptogenic cirrhosis, and in the context of liver transplantation. In hepatitis C, diagnosis of CD can be important as a relative contraindication to interferon use. Gluten-free diet ameliorates the symptoms associated with CD; however, the associated liver disease may improve, remain the same, or progress.

Keywords: Autoimmune; Biliary; Celiac disease; Cholangitis; Hepatitis; Hypertension; Liver cirrhosis; Portal; Sclerosing.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest statement: None declared.

References

    1. Spijkerman M, Tan IL, Kolkman JJ, Withoff S, Wijmenga C, Visschedijk MC, Weersma RK. A large variety of clinical features and concomitant disorders in celiac disease - A cohort study in the Netherlands. Dig Liver Dis. 2016;48:499–505. - PubMed
    1. Di Sabatino A, Corazza GR. Coeliac disease. Lancet. 2009;373:1480–1493. - PubMed
    1. Leffler DA, Green PH, Fasano A. Extraintestinal manifestations of coeliac disease. Nat Rev Gastroenterol Hepatol. 2015;12:561–571. - PubMed
    1. Narciso JL, Cabral VLR. Regression of subcutaneous sarcoid nodule and disappearance of thyroid-related autoantibodies with a gluten-free diet. GED gastroenterol endosc dig. 2006;25:170–172.
    1. Freeman HJ. Endocrine manifestations in celiac disease. World J Gastroenterol. 2016;22:8472–8479. - PMC - PubMed

MeSH terms