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. 2017 Apr 1;74(4):454-458.
doi: 10.1097/QAI.0000000000001259.

Brief Report: CD14+ Enriched Peripheral Cells Secrete Cytokines Unique to HIV-Associated Neurocognitive Disorders

Melissa A Agsalda-Garcia  1 , Pasiri Sithinamsuwan, Victor G Valcour, Thep Chalermchai, Somporn Tipsuk, Jason Kuroda, Christie Nakamura, Jintanat Ananworanich, Guangxiang Zhang, Alexandra Schuetz, Bonnie M Slike, Bruce Shiramizu; SEARCH 011 Study Group
Affiliations

Brief Report: CD14+ Enriched Peripheral Cells Secrete Cytokines Unique to HIV-Associated Neurocognitive Disorders

Melissa A Agsalda-Garcia et al. J Acquir Immune Defic Syndr. .

Abstract

Monocytes play a vital role in HIV-associated neurocognitive disorder (HAND), postulated to transport HIV into the brain and secrete pro-inflammatory cytokines. We analyzed cytokines released by cultured peripheral blood mononuclear cells enriched with the CD14 marker isolated from HIV-infected individuals with HAND and normal cognition (NC) in combination antiretroviral therapy naive and after 1 year on treatment. Interleukin-8 and monocyte chemoattractant protein-1 levels were higher in HAND compared with NC at baseline (P = 0.002 and P < 0.0001). These cytokines remained higher in HAND patients 1 year after combination antiretroviral therapy and were significant when NC patients who were initially HAND were excluded (P = 0.012 and P = 0.002). Both correlated with baseline CD14 peripheral blood mononuclear cell HIV DNA levels supporting the role of HIV DNA reservoir size and monocyte cytokines in HAND persistence.

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Figures

Figure 1
Figure 1
A) Monocyte IL-8 secretions between HAND and NC at entry; B) Monocyte MCP-1 secretions between HAND and NC at entry; C) Monocyte IL-8 secretions between HAND and NC after one year of cART; D)Monocyte MCP-1 secretions between HAND and NC after one year of cART; E) Monocyte IL-8 secretions between HAND, NC, and HAND that become NC after one year of cART; F) Monocyte MCP-1 secretions between HAND, NC, and HAND that became NC.
Figure 2
Figure 2
A) Non-parametric Spearman correlation between HIV DNA and IL-8; B) Non-parametric Spearman correlation between HIV DNA and MCP-1.
See this image and copyright information in PMC

References

    1. González-Scarano F, Martín-García J. The neuropathogenesis of AIDS. Nature Reviews Immunology. 2005;5:69–81. - PubMed
    1. Gartner S, Liu Y. Insights into the role of immune activation in HIV neuropathogenesis. J Neurovirol. 2002 Apr;8(2):69–75. - PubMed
    1. Verani A, Gras G, Pancino G. Macrophages and HIV-1: dangerous liaisons. Mol Immunol. 2005 Feb;42(2):195–212. - PubMed
    1. Fischer-Smith T, Bell C, Croul S, et al. Monocyte/macrophage trafficking in acquired immunodeficiency syndrome encephalitis: lessons from human and nonhuman primate studies. J Neurovirol. 2008 Aug;14(4):318–26. - PMC - PubMed
    1. Kusao I, Shiramizu B, Liang CY, et al. Cognitive performance related to HIV-1-infected monocytes. J Neuropsychiatry Clin Neurosci. 2012 Winter;24(1):71–80. - PMC - PubMed

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