Tumorigenesis: Extra! Extra! Read all about it!

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Anna Dart. Nat Rev Cancer. 2017.

. 2017 Feb 23;17(3):143.

doi: 10.1038/nrc.2017.12.

No abstract available

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The PIDDosome activates p53 in response to supernumerary centrosomes.
Fava LL, Schuler F, Sladky V, Haschka MD, Soratroi C, Eiterer L, Demetz E, Weiss G, Geley S, Nigg EA, Villunger A. Fava LL, et al. Genes Dev. 2017 Jan 1;31(1):34-45. doi: 10.1101/gad.289728.116. Genes Dev. 2017. PMID: 28130345 Free PMC article.
Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals.
Levine MS, Bakker B, Boeckx B, Moyett J, Lu J, Vitre B, Spierings DC, Lansdorp PM, Cleveland DW, Lambrechts D, Foijer F, Holland AJ. Levine MS, et al. Dev Cell. 2017 Feb 6;40(3):313-322.e5. doi: 10.1016/j.devcel.2016.12.022. Epub 2017 Jan 26. Dev Cell. 2017. PMID: 28132847 Free PMC article.